FHL1 (four and a half LIM domains 1)

2007-02-01  

Identity

HGNC
FHL1
LOCATION
Xq26.3
LOCUSID
2273
ALIAS
FCMSU,FHL-1,FHL1A,FHL1B,FLH1A,KYOT,RBMX1A,RBMX1B,SLIM,SLIM-1,SLIM1,SLIMMER,XMPMA
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2273
MIM: 300163
HGNC: 3702
Ensembl: ENSG00000022267

Variants:

dbSNP: 2273
ClinVar: 2273
TCGA: ENSG00000022267
COSMIC: FHL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000022267ENST00000370674Q5JXI8
ENSG00000022267ENST00000370676Q5JXI2
ENSG00000022267ENST00000370683Q13642
ENSG00000022267ENST00000394153Q13642
ENSG00000022267ENST00000394155Q13642
ENSG00000022267ENST00000420362Q5JXH8
ENSG00000022267ENST00000434885Q5JXI3
ENSG00000022267ENST00000449474Q5JXI0
ENSG00000022267ENST00000452016Q5JXI3
ENSG00000022267ENST00000456445Q5JXH7
ENSG00000022267ENST00000458357Q5JXH9
ENSG00000022267ENST00000535737Q13642
ENSG00000022267ENST00000539015Q13642
ENSG00000022267ENST00000543669Q13642
ENSG00000022267ENST00000618438Q13642
ENSG00000022267ENST00000625935A0A0D9SGC5
ENSG00000022267ENST00000627383A0A0D9SGB2
ENSG00000022267ENST00000627578A0A0D9SFB0
ENSG00000022267ENST00000627812A0A0D9SEY7
ENSG00000022267ENST00000628032A0A0D9SFZ9
ENSG00000022267ENST00000628443A0A0D9SFI6
ENSG00000022267ENST00000628568Q13642
ENSG00000022267ENST00000628919Q13642
ENSG00000022267ENST00000629039Q13642
ENSG00000022267ENST00000630084Q13642
ENSG00000022267ENST00000630278A0A0D9SGD1
ENSG00000022267ENST00000651089Q13642
ENSG00000022267ENST00000651256A0A494C1G1
ENSG00000022267ENST00000651929Q13642
ENSG00000022267ENST00000652457A0A494C0D6
ENSG00000022267ENST00000652745A0A494C0J3

Expression (GTEx)

0
500
1000
1500
2000
2500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Jak-STAT signaling pathwayKEGGko04630
Jak-STAT signaling pathwayKEGGhsa04630

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383241672024Low FHL1 expression indicates a good prognosis and drug sensitivity in ovarian cancer.0
383241672024Low FHL1 expression indicates a good prognosis and drug sensitivity in ovarian cancer.0
351429562023Immortalization-upregulated protein promotes pancreatic cancer progression by regulating NPM1/FHL1-mediated cell-cycle-checkpoint protein activity.2
366951312023FHL1 as a novel prognostic biomarker and correlation with immune infiltration levels in lung adenocarcinoma.1
368642872023Identification of novel FHL1 mutations associated with X-linked scapuloperoneal myopathy in unrelated Chinese patients.0
368819732023Preferential production and secretion of the complement regulator factor H-like protein 1 (FHL-1) by human myeloid cells.0
351429562023Immortalization-upregulated protein promotes pancreatic cancer progression by regulating NPM1/FHL1-mediated cell-cycle-checkpoint protein activity.2
366951312023FHL1 as a novel prognostic biomarker and correlation with immune infiltration levels in lung adenocarcinoma.1
368642872023Identification of novel FHL1 mutations associated with X-linked scapuloperoneal myopathy in unrelated Chinese patients.0
368819732023Preferential production and secretion of the complement regulator factor H-like protein 1 (FHL-1) by human myeloid cells.0
352494712022Upregulation of FHL1, SPNS3, and MPZL2 predicts poor prognosis in pediatric acute myeloid leukemia patients with FLT3-ITD mutation.4
356079172022Three novel FHL1 variants cause a mild phenotype of Emery-Dreifuss muscular dystrophy.1
359163392022Targeting FHL1 impairs cell proliferation and differentiation of acute myeloid leukemia cells.0
360171482022MiR-96-5p Facilitates Lung Adenocarcinoma Cell Phenotypes by Inhibiting FHL1.2
352494712022Upregulation of FHL1, SPNS3, and MPZL2 predicts poor prognosis in pediatric acute myeloid leukemia patients with FLT3-ITD mutation.4

Citation

Dessen P

FHL1 (four and a half LIM domains 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45582/tumors-explorer/js/lib/favicon/apple-touch-icon.png