INSL3 (insulin like 3)

2007-02-01 Affiliation

Identity

HGNC

INSL3

LOCATION

19p13.11

LOCUSID

3640

ALIAS

RLF,RLNL,ley-I-L

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3640
MIM: 146738
HGNC: 6086
Ensembl: ENSG00000248099

Variants:

dbSNP: 3640
ClinVar: 3640
TCGA: ENSG00000248099
COSMIC: INSL3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000248099	ENST00000317306	P51460
ENSG00000248099	ENST00000379695	P51460
ENSG00000248099	ENST00000598577	M0QXQ3

Expression (GTEx)

100

150

200

250

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Peptide ligand-binding receptors	REACTOME	R-HSA-375276
Relaxin receptors	REACTOME	R-HSA-444821
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (s) signalling events	REACTOME	R-HSA-418555

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
37421657	2024	The impact of acute SARS-CoV-2 on testicular function including insulin-like factor 3 (INSL3) in men with mild COVID-19: A longitudinal study.	1
37421657	2024	The impact of acute SARS-CoV-2 on testicular function including insulin-like factor 3 (INSL3) in men with mild COVID-19: A longitudinal study.	1
37208861	2023	Bi-allelic variants in INSL3 and RXFP2 cause bilateral cryptorchidism and male infertility.	1
37830594	2023	New JAK3-INSL3 Fusion Transcript-An Oncogenic Event in Cutaneous T-Cell Lymphoma.	2
37208861	2023	Bi-allelic variants in INSL3 and RXFP2 cause bilateral cryptorchidism and male infertility.	1
37830594	2023	New JAK3-INSL3 Fusion Transcript-An Oncogenic Event in Cutaneous T-Cell Lymphoma.	2
35464060	2022	Expression and Role of INSL3 in the Fetal Testis.	10
35666805	2022	The nuclear receptors SF1 and COUP-TFII cooperate on the Insl3 promoter in Leydig cells.	6
35464060	2022	Expression and Role of INSL3 in the Fetal Testis.	10
35666805	2022	The nuclear receptors SF1 and COUP-TFII cooperate on the Insl3 promoter in Leydig cells.	6
33041054	2021	New theca-cell marker insulin-like factor 3 is associated with premature ovarian insufficiency.	4
34233048	2021	Clinical value of INSL3 in the diagnosis and development of diabetic nephropathy.	5
34447353	2021	Serum Concentrations and Gonadal Expression of INSL3 in Eighteen Males With 45,X/46,XY Mosaicism.	1
33041054	2021	New theca-cell marker insulin-like factor 3 is associated with premature ovarian insufficiency.	4
34233048	2021	Clinical value of INSL3 in the diagnosis and development of diabetic nephropathy.	5

Citation

Dessen P

INSL3 (insulin like 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45583/js/favicon/favicon-32x32.png