CD3E (CD3e molecule)

2007-02-01  

Identity

HGNC
CD3E
LOCATION
11q23.3
LOCUSID
916
ALIAS
IMD18,T3E,TCRE
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 916
MIM: 186830
HGNC: 1674
Ensembl: ENSG00000198851

Variants:

dbSNP: 916
ClinVar: 916
TCGA: ENSG00000198851
COSMIC: CD3E

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198851ENST00000361763P07766
ENSG00000198851ENST00000528600E9PSH8

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Hematopoietic cell lineageKEGGko04640
T cell receptor signaling pathwayKEGGko04660
Primary immunodeficiencyKEGGko05340
Hematopoietic cell lineageKEGGhsa04640
T cell receptor signaling pathwayKEGGhsa04660
Primary immunodeficiencyKEGGhsa05340
Chagas disease (American trypanosomiasis)KEGGko05142
Chagas disease (American trypanosomiasis)KEGGhsa05142
MeaslesKEGGko05162
MeaslesKEGGhsa05162
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
TCR signalingREACTOMER-HSA-202403
Phosphorylation of CD3 and TCR zeta chainsREACTOMER-HSA-202427
Translocation of ZAP-70 to Immunological synapseREACTOMER-HSA-202430
Generation of second messenger moleculesREACTOMER-HSA-202433
Downstream TCR signalingREACTOMER-HSA-202424
Costimulation by the CD28 familyREACTOMER-HSA-388841
PD-1 signalingREACTOMER-HSA-389948
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933
Th1 and Th2 cell differentiationKEGGko04658
Th1 and Th2 cell differentiationKEGGhsa04658
Th17 cell differentiationKEGGko04659
Th17 cell differentiationKEGGhsa04659

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
357108692022Low transcriptomic of PTPRCv1 and CD3E is an independent predictor of mortality in HIV and tuberculosis co-infected patient.0
357108692022Low transcriptomic of PTPRCv1 and CD3E is an independent predictor of mortality in HIV and tuberculosis co-infected patient.0
316746572020Actin polymerization regulates recruitment of Nck to CD3ε upon T-cell receptor triggering.5
320166512020Biallelic Form of a Known CD3E Mutation in a Patient with Severe Combined Immunodeficiency.4
327308082020Multiple Signaling Roles of CD3ε and Its Application in CAR-T Cell Therapy.65
316746572020Actin polymerization regulates recruitment of Nck to CD3ε upon T-cell receptor triggering.5
320166512020Biallelic Form of a Known CD3E Mutation in a Patient with Severe Combined Immunodeficiency.4
327308082020Multiple Signaling Roles of CD3ε and Its Application in CAR-T Cell Therapy.65
285973652017A novel pathogenic frameshift variant of CD3E gene in two T-B+ NK+ SCID patients from Turkey.7
286594682017Ionic CD3-Lck interaction regulates the initiation of T-cell receptor signaling.49
285973652017A novel pathogenic frameshift variant of CD3E gene in two T-B+ NK+ SCID patients from Turkey.7
286594682017Ionic CD3-Lck interaction regulates the initiation of T-cell receptor signaling.49
268280962016The Transmembrane Domain of HIV-1 gp41 Inhibits T-Cell Activation by Targeting Multiple T-Cell Receptor Complex Components through Its GxxxG Motif.10
268886262016Change in CD3ζ-chain expression is an independent predictor of disease status in head and neck cancer patients.11
277548692016The Stalk Domain of NKp30 Contributes to Ligand Binding and Signaling of a Preassembled NKp30-CD3ζ Complex.6

Citation

Dessen P

CD3E (CD3e molecule)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45585