GIT2 (GIT ArfGAP 2)

2007-02-01  

Identity

HGNC
GIT2
LOCATION
12q24.11
LOCUSID
9815
ALIAS
CAT-2,CAT2,PKL
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9815
MIM: 608564
HGNC: 4273
Ensembl: ENSG00000139436

Variants:

dbSNP: 9815
ClinVar: 9815
TCGA: ENSG00000139436
COSMIC: GIT2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000139436ENST00000320063F8W822
ENSG00000139436ENST00000354574F8WAK2
ENSG00000139436ENST00000355312Q14161
ENSG00000139436ENST00000361006Q14161
ENSG00000139436ENST00000457474Q14161
ENSG00000139436ENST00000547815Q14161
ENSG00000139436ENST00000547815Q6FI58
ENSG00000139436ENST00000550186R4GNG3
ENSG00000139436ENST00000551209F8VXI9
ENSG00000139436ENST00000553118Q14161

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
371569992023Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries.28
371569992023Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries.28
327436952020Long non-coding RNA MALAT1 promotes odontogenic differentiation of human dental pulp stem cells by impairing microRNA-140-5p-dependent downregulation of GIT2.8
327436952020Long non-coding RNA MALAT1 promotes odontogenic differentiation of human dental pulp stem cells by impairing microRNA-140-5p-dependent downregulation of GIT2.8
309154692019GIT2 deficiency attenuates inflammation-induced expression of pro-labor mediators in human amnion and myometrial cells†.2
309154692019GIT2 deficiency attenuates inflammation-induced expression of pro-labor mediators in human amnion and myometrial cells†.2
276694372017The focal adhesion-associated proteins DOCK5 and GIT2 comprise a rheostat in control of epithelial invasion.19
276694372017The focal adhesion-associated proteins DOCK5 and GIT2 comprise a rheostat in control of epithelial invasion.19
271820612016Expanding functions of GIT Arf GTPase-activating proteins, PIX Rho guanine nucleotide exchange factors and GIT-PIX complexes.63
272385702016EGF-stimulated activation of Rab35 regulates RUSC2-GIT2 complex formation to stabilize GIT2 during directional lung cancer cell migration.19
271820612016Expanding functions of GIT Arf GTPase-activating proteins, PIX Rho guanine nucleotide exchange factors and GIT-PIX complexes.63
272385702016EGF-stimulated activation of Rab35 regulates RUSC2-GIT2 complex formation to stabilize GIT2 during directional lung cancer cell migration.19
256053342015Nuclear GIT2 is an ATM substrate and promotes DNA repair.17
256053342015Nuclear GIT2 is an ATM substrate and promotes DNA repair.17
235918152013Loss of Git2 induces epithelial-mesenchymal transition by miR146a-Cnot6L-controlled expression of Zeb1.7

Citation

Dessen P

GIT2 (GIT ArfGAP 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45589