SCGN (secretagogin, EF-hand calcium binding protein)

2007-02-01 Affiliation

Identity

HGNC

SCGN

LOCATION

6p22.2

LOCUSID

10590

ALIAS

CALBL,DJ501N12.8,SECRET,SEGN,setagin

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 10590
MIM: 609202
HGNC: 16941
Ensembl: ENSG00000079689

Variants:

dbSNP: 10590
ClinVar: 10590
TCGA: ENSG00000079689
COSMIC: SCGN

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000079689	ENST00000334979	Q96P10
ENSG00000079689	ENST00000377961	O76038
ENSG00000079689	ENST00000612225	Q96P10

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
36588101	2023	SCGN deficiency is a risk factor for autism spectrum disorder.	9
36588101	2023	SCGN deficiency is a risk factor for autism spectrum disorder.	9
31512254	2020	Differential expression of secretagogin immunostaining in the hippocampal formation and the entorhinal and perirhinal cortices of humans, rats, and mice.	10
31512254	2020	Differential expression of secretagogin immunostaining in the hippocampal formation and the entorhinal and perirhinal cortices of humans, rats, and mice.	10
31663849	2019	SCGN deficiency results in colitis susceptibility.	12
31663849	2019	SCGN deficiency results in colitis susceptibility.	12
29499408	2018	Overexpression of secretagogin promotes cell apoptosis and inhibits migration and invasion of human SW480 human colorectal cancer cells.	2
29702679	2018	Secretagogin is increased in plasma from type 2 diabetes patients and potentially reflects stress and islet dysfunction.	7
29499408	2018	Overexpression of secretagogin promotes cell apoptosis and inhibits migration and invasion of human SW480 human colorectal cancer cells.	2
29702679	2018	Secretagogin is increased in plasma from type 2 diabetes patients and potentially reflects stress and islet dysfunction.	7
28223495	2017	Secretagogin-dependent matrix metalloprotease-2 release from neurons regulates neuroblast migration.	16
28325894	2017	SUMOylation and calcium control syntaxin-1A and secretagogin sequestration by tomosyn to regulate insulin exocytosis in human ß cells.	23
28492151	2017	Secretagogin (SCGN) Plasma Levels and their Association with Cognitive and Social Behavior in Children with Autism Spectrum Disorder ASD).	3
28637794	2017	A TRPV1-to-secretagogin regulatory axis controls pancreatic β-cell survival by modulating protein turnover.	32
28223495	2017	Secretagogin-dependent matrix metalloprotease-2 release from neurons regulates neuroblast migration.	16

Citation

Dessen P

SCGN (secretagogin, EF-hand calcium binding protein)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45603/favicon/css/card-gene.css