HRH4 (histamine receptor H4)

2007-02-01  

Identity

HGNC
HRH4
LOCATION
18q11.2
LOCUSID
59340
ALIAS
AXOR35,BG26,GPCR105,GPRv53,H4,H4R,HH4R
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 59340
MIM: 606792
HGNC: 17383
Ensembl: ENSG00000134489

Variants:

dbSNP: 59340
ClinVar: 59340
TCGA: ENSG00000134489
COSMIC: HRH4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134489ENST00000256906Q9H3N8
ENSG00000134489ENST00000426880Q9H3N8

Expression (GTEx)

0
1
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Amine ligand-binding receptorsREACTOMER-HSA-375280
Histamine receptorsREACTOMER-HSA-390650
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA447216SchizophreniaDiseaseClinicalAnnotationassociatedPD23422377
PA451257risperidoneChemicalClinicalAnnotationassociatedPD23422377

References

Pubmed IDYearTitleCitations
373007032023Histamine H(1)- and H(4)-receptor expression in human colon-derived cell lines.0
373007032023Histamine H(1)- and H(4)-receptor expression in human colon-derived cell lines.0
344322562022Histamine-4 Receptor: Emerging Target for the Treatment of Neurological Diseases.2
351633022022Histamine H4 Receptor Agonism Induces Antitumor Effects in Human T-Cell Lymphoma.5
352271092022Histamine H4 Receptor Expression in Triple-negative Breast Cancer: An Exploratory Study.2
360910662022Unraveling the venom chemistry with evidence for histamine as key regulator in the envenomation by caterpillar Automeris zaruma.4
344322562022Histamine-4 Receptor: Emerging Target for the Treatment of Neurological Diseases.2
351633022022Histamine H4 Receptor Agonism Induces Antitumor Effects in Human T-Cell Lymphoma.5
352271092022Histamine H4 Receptor Expression in Triple-negative Breast Cancer: An Exploratory Study.2
360910662022Unraveling the venom chemistry with evidence for histamine as key regulator in the envenomation by caterpillar Automeris zaruma.4
344397932021Identification of TSPAN4 as Novel Histamine H(4) Receptor Interactor.6
344397932021Identification of TSPAN4 as Novel Histamine H(4) Receptor Interactor.6
317487402020Study of the antitumour effects and the modulation of immune response by histamine in breast cancer.12
317487402020Study of the antitumour effects and the modulation of immune response by histamine in breast cancer.12
307670142019Human H4 tail stimulates HIV-1 integration through binding to the carboxy-terminal domain of integrase.9

Citation

Dessen P

HRH4 (histamine receptor H4)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45609