NQO2 (N-ribosyldihydronicotinamide:quinone reductase 2)

2007-02-01  

Identity

HGNC
NQO2
LOCATION
6p25.2
LOCUSID
4835
ALIAS
DHQV,DIA6,NMOR2,QR2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4835
MIM: 160998
HGNC: 7856
Ensembl: ENSG00000124588

Variants:

dbSNP: 4835
ClinVar: 4835
TCGA: ENSG00000124588
COSMIC: NQO2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124588ENST00000338130P16083
ENSG00000124588ENST00000380430P16083
ENSG00000124588ENST00000380441Q5TD07
ENSG00000124588ENST00000380454Q5TD07
ENSG00000124588ENST00000380455P16083
ENSG00000124588ENST00000380472Q5TD05
ENSG00000124588ENST00000397717Q5TD05
ENSG00000124588ENST00000426637A2A2U4
ENSG00000124588ENST00000606474U3KQG7

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443560Breast NeoplasmsDiseaseClinicalAnnotationassociatedPD21946896, 29938344
PA449165cyclophosphamideChemicalClinicalAnnotationassociatedPD21946896, 29938344
PA449412doxorubicinChemicalClinicalAnnotationassociatedPD21946896, 29938344

References

Pubmed IDYearTitleCitations
382549762024Polymorphisms and Pharmacogenomics of NQO2: The Past and the Future.1
382549762024Polymorphisms and Pharmacogenomics of NQO2: The Past and the Future.1
361426072022An Axis between the Long Non-Coding RNA HOXA11-AS and NQOs Enhances Metastatic Ability in Oral Squamous Cell Carcinoma.5
361426072022An Axis between the Long Non-Coding RNA HOXA11-AS and NQOs Enhances Metastatic Ability in Oral Squamous Cell Carcinoma.5
314315152019Cancer-associated variants of human NQO1: impacts on inhibitor binding and cooperativity.6
314315152019Cancer-associated variants of human NQO1: impacts on inhibitor binding and cooperativity.6
295268072018Oxidative stress and neurodegeneration: The possible contribution of quinone reductase 2.13
295268072018Oxidative stress and neurodegeneration: The possible contribution of quinone reductase 2.13
283467332017The ontogeny and population variability of human hepatic dihydronicotinamide riboside:quinone oxidoreductase (NQO2).3
283467332017The ontogeny and population variability of human hepatic dihydronicotinamide riboside:quinone oxidoreductase (NQO2).3
266091532015Expression of Quinone Reductase-2 in the Cortex Is a Muscarinic Acetylcholine Receptor-Dependent Memory Consolidation Constraint.13
266091532015Expression of Quinone Reductase-2 in the Cortex Is a Muscarinic Acetylcholine Receptor-Dependent Memory Consolidation Constraint.13
246315402014The two common polymorphic forms of human NRH-quinone oxidoreductase 2 (NQO2) have different biochemical properties.12
246315402014The two common polymorphic forms of human NRH-quinone oxidoreductase 2 (NQO2) have different biochemical properties.12
234719722013Chloroquine binding reveals flavin redox switch function of quinone reductase 2.12

Citation

Dessen P

NQO2 (N-ribosyldihydronicotinamide:quinone reductase 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45617