EIF4G2 (eukaryotic translation initiation factor 4 gamma 2)

2007-02-01  

Identity

HGNC
EIF4G2
LOCATION
11p15.4
LOCUSID
1982
ALIAS
AAG1,DAP5,NAT1,P97
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1982
MIM: 602325
HGNC: 3297
Ensembl: ENSG00000110321

Variants:

dbSNP: 1982
ClinVar: 1982
TCGA: ENSG00000110321
COSMIC: EIF4G2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110321ENST00000339995D3DQV9
ENSG00000110321ENST00000396525H0Y3P2
ENSG00000110321ENST00000524932H0YEC5
ENSG00000110321ENST00000525681D3DQV9
ENSG00000110321ENST00000526148D3DQV9
ENSG00000110321ENST00000527419H0YE44
ENSG00000110321ENST00000527526H0YEN8
ENSG00000110321ENST00000528562H0YE87
ENSG00000110321ENST00000528839H0YE22
ENSG00000110321ENST00000530211H0YDC0
ENSG00000110321ENST00000530702H0YEI7
ENSG00000110321ENST00000531180E9PKF8
ENSG00000110321ENST00000531416H0YCH5
ENSG00000110321ENST00000531647H0YD99
ENSG00000110321ENST00000532082H0YD77
ENSG00000110321ENST00000532570H0YCF8
ENSG00000110321ENST00000534605H0YEW3

Expression (GTEx)

0
100
200
300
400
500
600
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Viral myocarditisKEGGhsa05416
RNA transportKEGGko03013
RNA transportKEGGhsa03013
eIF4F complexKEGGhsa_M00428
eIF4F complexKEGGM00428
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Antiviral mechanism by IFN-stimulated genesREACTOMER-HSA-1169410
ISG15 antiviral mechanismREACTOMER-HSA-1169408

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381290982024Loss-of-function cancer-linked mutations in the EIF4G2 non-canonical translation initiation factor.1
383428892024MicroRNA-877-5p promotes osteoblast differentiation by targeting EIF4G2 expression.0
381290982024Loss-of-function cancer-linked mutations in the EIF4G2 non-canonical translation initiation factor.1
383428892024MicroRNA-877-5p promotes osteoblast differentiation by targeting EIF4G2 expression.0
365470082023Eukaryotic translation initiation factor eIF4G2 opens novel paths for protein synthesis in development, apoptosis and cell differentiation.5
371444682023Translational fidelity screens in mammalian cells reveal eIF3 and eIF4G2 as regulators of start codon selectivity.5
373149292023Breast cancer cell mesenchymal transition and metastasis directed by DAP5/eIF3d-mediated selective mRNA translation.10
376466102023miR-379-5P INHIBITION ENHANCES INTESTINAL EPITHELIAL PROLIFERATION AND BARRIER FUNCTION RECOVERY AFTER ISCHEMIA/REPERFUSION BY TARGETING EIF4G2.1
365470082023Eukaryotic translation initiation factor eIF4G2 opens novel paths for protein synthesis in development, apoptosis and cell differentiation.5
371444682023Translational fidelity screens in mammalian cells reveal eIF3 and eIF4G2 as regulators of start codon selectivity.5
373149292023Breast cancer cell mesenchymal transition and metastasis directed by DAP5/eIF3d-mediated selective mRNA translation.10
376466102023miR-379-5P INHIBITION ENHANCES INTESTINAL EPITHELIAL PROLIFERATION AND BARRIER FUNCTION RECOVERY AFTER ISCHEMIA/REPERFUSION BY TARGETING EIF4G2.1
351961972022Circular RNA-UBE2D2 accelerates the proliferation and metastasis of non-small cell lung cancer cells via modulating microRNA-376a-3p/Eukaryotic Translation Initiation Factor 4γ2 axis.4
359617522022DAP5 drives translation of specific mRNA targets with upstream ORFs in human embryonic stem cells.11
351961972022Circular RNA-UBE2D2 accelerates the proliferation and metastasis of non-small cell lung cancer cells via modulating microRNA-376a-3p/Eukaryotic Translation Initiation Factor 4γ2 axis.4

Citation

Dessen P

EIF4G2 (eukaryotic translation initiation factor 4 gamma 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45619/gene-fusions-explorer/cancer-prone-explorer/js/lib/jquery-3.5.1.min.js