CBX1 (chromobox 1)

2007-02-01  

Identity

HGNC
CBX1
LOCATION
17q21.32
LOCUSID
10951
ALIAS
CBX,HP1-BETA,HP1Hs-beta,HP1Hsbeta,M31,MOD1,p25beta
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10951
MIM: 604511
HGNC: 1551
Ensembl: ENSG00000108468

Variants:

dbSNP: 10951
ClinVar: 10951
TCGA: ENSG00000108468
COSMIC: CBX1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108468ENST00000225603P83916
ENSG00000108468ENST00000225603Q6IBN6
ENSG00000108468ENST00000393408P83916
ENSG00000108468ENST00000393408Q6IBN6
ENSG00000108468ENST00000402583B5MD17
ENSG00000108468ENST00000444685C9JWS9
ENSG00000108468ENST00000495350K7ELA4
ENSG00000108468ENST00000581003J3KS05

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
363101392022N(6) -Methyladenosine-Modified CBX1 Regulates Nasopharyngeal Carcinoma Progression Through Heterochromatin Formation and STAT1 Activation.5
363101392022N(6) -Methyladenosine-Modified CBX1 Regulates Nasopharyngeal Carcinoma Progression Through Heterochromatin Formation and STAT1 Activation.5
334606842021Beyond the Nucleosome: Nucleosome-Protein Interactions and Higher Order Chromatin Structure.5
336611002021HP1 proteins compact DNA into mechanically and positionally stable phase separated domains.81
334606842021Beyond the Nucleosome: Nucleosome-Protein Interactions and Higher Order Chromatin Structure.5
336611002021HP1 proteins compact DNA into mechanically and positionally stable phase separated domains.81
315333402019DNA Damage Changes Distribution Pattern and Levels of HP1 Protein Isoforms in the Nucleolus and Increases Phosphorylation of HP1β-Ser88.6
315333402019DNA Damage Changes Distribution Pattern and Levels of HP1 Protein Isoforms in the Nucleolus and Increases Phosphorylation of HP1β-Ser88.6
282233592017Peptide recognition by heterochromatin protein 1 (HP1) chromoshadow domains revisited: Plasticity in the pseudosymmetric histone binding site of human HP1.16
282233592017Peptide recognition by heterochromatin protein 1 (HP1) chromoshadow domains revisited: Plasticity in the pseudosymmetric histone binding site of human HP1.16
270904912016Dynamic and flexible H3K9me3 bridging via HP1β dimerization establishes a plastic state of condensed chromatin.65
270904912016Dynamic and flexible H3K9me3 bridging via HP1β dimerization establishes a plastic state of condensed chromatin.65
257690252015HP1β is a biomarker for breast cancer prognosis and PARP inhibitor therapy.22
257690252015HP1β is a biomarker for breast cancer prognosis and PARP inhibitor therapy.22
245611992014Characterization of the effects of phosphorylation by CK2 on the structure and binding properties of human HP1β.10

Citation

Dessen P

CBX1 (chromobox 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45621/meetings/js/lib/teaching-explorer/