UCP2 (uncoupling protein 2)

2007-02-01  

Identity

HGNC
LOCATION
11q13.4
LOCUSID
ALIAS
BMIQ4,SLC25A8,UCPH
FUSION GENES

Other Information

Locus ID:

NCBI: 7351
MIM: 601693
HGNC: 12518
Ensembl: ENSG00000175567

Variants:

dbSNP: 7351
ClinVar: 7351
TCGA: ENSG00000175567
COSMIC: UCP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000175567ENST00000310473P55851
ENSG00000175567ENST00000310473A0A024R5N5
ENSG00000175567ENST00000536983F5GX45
ENSG00000175567ENST00000539764F5H312
ENSG00000175567ENST00000545212H0YFQ0
ENSG00000175567ENST00000663595P55851
ENSG00000175567ENST00000663595A0A024R5N5

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transportREACTOMER-HSA-1428517
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.REACTOMER-HSA-163200
Mitochondrial Uncoupling ProteinsREACTOMER-HSA-166187
The fatty acid cycling modelREACTOMER-HSA-167826
The proton buffering modelREACTOMER-HSA-167827

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
382173032024UCP2 promotes NSCLC proliferation and glycolysis via the mTOR/HIF-1α signaling.1
382173032024UCP2 promotes NSCLC proliferation and glycolysis via the mTOR/HIF-1α signaling.1
363464922023Mitochondrial uncoupling protein 2 (UCP2) gene polymorphism - 866 G/A in the promoter region is associated with type 2 diabetes mellitus among Kashmiri population of Northern India.2
366517112023Expressions of mRNA and encoded proteins of mitochondrial uncoupling protein genes (UCP1, UCP2, and UCP3) in epicardial and mediastinal adipose tissue and associations with coronary artery disease.2
368333882023Association between Polymorphism of Genes IL-1A, NFKB1, PAR1, TP53, and UCP2 and Susceptibility to Non-Small Cell Lung Cancer in the Brazilian Amazon.3
371758292023Role of UCP2 in the Energy Metabolism of the Cancer Cell Line A549.1
377442772023CircUCP2 promotes the tumor progression of non-small cell lung cancer through the miR-149/UCP2 pathway.5
363464922023Mitochondrial uncoupling protein 2 (UCP2) gene polymorphism - 866 G/A in the promoter region is associated with type 2 diabetes mellitus among Kashmiri population of Northern India.2
366517112023Expressions of mRNA and encoded proteins of mitochondrial uncoupling protein genes (UCP1, UCP2, and UCP3) in epicardial and mediastinal adipose tissue and associations with coronary artery disease.2
368333882023Association between Polymorphism of Genes IL-1A, NFKB1, PAR1, TP53, and UCP2 and Susceptibility to Non-Small Cell Lung Cancer in the Brazilian Amazon.3
371758292023Role of UCP2 in the Energy Metabolism of the Cancer Cell Line A549.1
377442772023CircUCP2 promotes the tumor progression of non-small cell lung cancer through the miR-149/UCP2 pathway.5
338828092022Uncoupling Protein 2 as a Pathogenic Determinant and Therapeutic Target in Cardiovascular and Metabolic Diseases.7
342878262022Uncoupling protein 2 and dynamin-related protein 1 mRNA expressions as genetic markers for plaque psoriasis.0
351290482022Impact of UCP2 depletion on heat stroke-induced mitochondrial function in human umbilical vein endothelial cells.6

Citation

Dessen P

UCP2 (uncoupling protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45629/ucp2