JAM3 (junctional adhesion molecule 3)

2007-02-01  

Identity

HGNC
JAM3
LOCATION
11q25
LOCUSID
83700
ALIAS
JAM-2,JAM-3,JAM-C,JAMC
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 83700
MIM: 606871
HGNC: 15532
Ensembl: ENSG00000166086

Variants:

dbSNP: 83700
ClinVar: 83700
TCGA: ENSG00000166086
COSMIC: JAM3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166086ENST00000299106Q9BX67
ENSG00000166086ENST00000441717Q9BX67
ENSG00000166086ENST00000532252H0YCW9
ENSG00000166086ENST00000534549H0YD98

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Tight junctionKEGGko04530
Leukocyte transendothelial migrationKEGGko04670
Epithelial cell signaling in Helicobacter pylori infectionKEGGko05120
Cell adhesion molecules (CAMs)KEGGhsa04514
Tight junctionKEGGhsa04530
Leukocyte transendothelial migrationKEGGhsa04670
Epithelial cell signaling in Helicobacter pylori infectionKEGGhsa05120
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
Extracellular matrix organizationREACTOMER-HSA-1474244
Integrin cell surface interactionsREACTOMER-HSA-216083

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381243992024Downregulation of JAM3 occurs in cholangiocarcinoma by hypermethylation: A potential molecular marker for diagnosis and prognosis.1
387608032024JAM3 promotes cervical cancer metastasis by activating the HIF-1α/VEGFA pathway.0
381243992024Downregulation of JAM3 occurs in cholangiocarcinoma by hypermethylation: A potential molecular marker for diagnosis and prognosis.1
387608032024JAM3 promotes cervical cancer metastasis by activating the HIF-1α/VEGFA pathway.0
384483752023High-grade cervical lesions diagnosed by JAM3/PAX1 methylation in high-risk human papillomavirus-infected patients.0
384483752023High-grade cervical lesions diagnosed by JAM3/PAX1 methylation in high-risk human papillomavirus-infected patients.0
348616792022Junctional adhesion molecule C expression specifies a CD138low/neg multiple myeloma cell population in mice and humans.6
350327922022The role of junctional adhesion molecule-C in trophoblast differentiation and function during normal pregnancy and preeclampsia.1
358185862022miR-127-5p Targets JAM3 to Regulate Ferroptosis, Proliferation, and Metastasis in Malignant Meningioma Cells.2
358715412022Decreased junctional adhesion molecule 3 expression induces reactive oxygen species production and apoptosis in trophoblasts†.2
364610922022Epigenetic silencing of JAM3 promotes esophageal cancer development by activating Wnt signaling.6
348616792022Junctional adhesion molecule C expression specifies a CD138low/neg multiple myeloma cell population in mice and humans.6
350327922022The role of junctional adhesion molecule-C in trophoblast differentiation and function during normal pregnancy and preeclampsia.1
358185862022miR-127-5p Targets JAM3 to Regulate Ferroptosis, Proliferation, and Metastasis in Malignant Meningioma Cells.2
358715412022Decreased junctional adhesion molecule 3 expression induces reactive oxygen species production and apoptosis in trophoblasts†.2

Citation

Dessen P

JAM3 (junctional adhesion molecule 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45647