MS4A1 (membrane spanning 4-domains A1)

2007-02-01  

Identity

HGNC
LOCATION
11q12.2
LOCUSID
ALIAS
B1,Bp35,CD20,CVID5,FMC7,LEU-16,MS4A2,S7

Other Information

Locus ID:

NCBI: 931
MIM: 112210
HGNC: 7315
Ensembl: ENSG00000156738

Variants:

dbSNP: 931
ClinVar: 931
TCGA: ENSG00000156738
COSMIC: MS4A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156738ENST00000345732P11836
ENSG00000156738ENST00000345732A0A024R507
ENSG00000156738ENST00000389939P11836
ENSG00000156738ENST00000389939A0A024R507
ENSG00000156738ENST00000528313P11836
ENSG00000156738ENST00000532073E9PKH8
ENSG00000156738ENST00000533306E9PPL6
ENSG00000156738ENST00000534668P11836
ENSG00000156738ENST00000534668A0A024R507
ENSG00000156738ENST00000674194A0A024R507

Expression (GTEx)

0
100
200
300
400
500
600

Pathways

PathwaySourceExternal ID
Hematopoietic cell lineageKEGGko04640
Hematopoietic cell lineageKEGGhsa04640

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164748364tositumomabChemicalLabelAnnotationassociated
PA164781375ibritumomabChemicalLabelAnnotationassociated
PA165291493ofatumumabChemicalLabelAnnotationassociated
PA166122586afutuzumabChemicalLabelAnnotation, MultilinkAnnotationassociated24795454
PA451261rituximabChemicalLabelAnnotationassociated

References

Pubmed IDYearTitleCitations
374334002023Novel cell subtypes of SPP1 + S100P+, MS4A1-SPP1 + S100P+ were key subpopulations in intrahepatic cholangiocarcinoma.1
374334002023Novel cell subtypes of SPP1 + S100P+, MS4A1-SPP1 + S100P+ were key subpopulations in intrahepatic cholangiocarcinoma.1
350915272022MS4A1 as a Potential Independent Prognostic Factor of Breast Cancer Related to Lipid Metabolism and Immune Microenvironment Based on TCGA Database Analysis.6
350915272022MS4A1 as a Potential Independent Prognostic Factor of Breast Cancer Related to Lipid Metabolism and Immune Microenvironment Based on TCGA Database Analysis.6
333524662021MS4A1 expression and function in T cells in the colorectal cancer tumor microenvironment.17
345427732021Differential effects of CD20+ B cells and PD-L1+ immune cells on pathologic complete response and outcome: comparison between inflammatory breast cancer and locally advanced breast cancer patients.4
346548262021CD20 positive CD8 T cells are a unique and transcriptionally-distinct subset of T cells with distinct transmigration properties.12
347431992021CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles.2
333524662021MS4A1 expression and function in T cells in the colorectal cancer tumor microenvironment.17
345427732021Differential effects of CD20+ B cells and PD-L1+ immune cells on pathologic complete response and outcome: comparison between inflammatory breast cancer and locally advanced breast cancer patients.4
346548262021CD20 positive CD8 T cells are a unique and transcriptionally-distinct subset of T cells with distinct transmigration properties.12
347431992021CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles.2
316823182020CD20-positive primary nasal peripheral T-cell lymphoma: An analysis of one case and review of the literature.1
320562022020STIM1 knock-down decreases the affinity of obinutuzumab for CD20 by altering CD20 localization to Triton-soluble membrane.1
320796802020Structure of CD20 in complex with the therapeutic monoclonal antibody rituximab.71

Citation

Dessen P

MS4A1 (membrane spanning 4-domains A1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45648/deep-insight-explorer/cancer-prone-explorer/favicon/favicon-16x16.png