MS4A1 (membrane spanning 4-domains A1)

2007-02-01  

Identity

HGNC
MS4A1
LOCATION
11q12.2
LOCUSID
931
ALIAS
B1,Bp35,CD20,CVID5,FMC7,LEU-16,MS4A2,S7

Other Information

Locus ID:

NCBI: 931
MIM: 112210
HGNC: 7315
Ensembl: ENSG00000156738

Variants:

dbSNP: 931
ClinVar: 931
TCGA: ENSG00000156738
COSMIC: MS4A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156738ENST00000345732P11836
ENSG00000156738ENST00000345732A0A024R507
ENSG00000156738ENST00000389939P11836
ENSG00000156738ENST00000389939A0A024R507
ENSG00000156738ENST00000528313P11836
ENSG00000156738ENST00000532073E9PKH8
ENSG00000156738ENST00000533306E9PPL6
ENSG00000156738ENST00000534668P11836
ENSG00000156738ENST00000534668A0A024R507
ENSG00000156738ENST00000674194A0A024R507

Expression (GTEx)

0
100
200
300
400
500
600
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Hematopoietic cell lineageKEGGko04640
Hematopoietic cell lineageKEGGhsa04640

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164748364tositumomabChemicalLabelAnnotationassociated
PA164781375ibritumomabChemicalLabelAnnotationassociated
PA165291493ofatumumabChemicalLabelAnnotationassociated
PA166122586afutuzumabChemicalLabelAnnotation, MultilinkAnnotationassociated24795454
PA451261rituximabChemicalLabelAnnotationassociated

References

Pubmed IDYearTitleCitations
374334002023Novel cell subtypes of SPP1 + S100P+, MS4A1-SPP1 + S100P+ were key subpopulations in intrahepatic cholangiocarcinoma.1
374334002023Novel cell subtypes of SPP1 + S100P+, MS4A1-SPP1 + S100P+ were key subpopulations in intrahepatic cholangiocarcinoma.1
350915272022MS4A1 as a Potential Independent Prognostic Factor of Breast Cancer Related to Lipid Metabolism and Immune Microenvironment Based on TCGA Database Analysis.6
350915272022MS4A1 as a Potential Independent Prognostic Factor of Breast Cancer Related to Lipid Metabolism and Immune Microenvironment Based on TCGA Database Analysis.6
333524662021MS4A1 expression and function in T cells in the colorectal cancer tumor microenvironment.17
345427732021Differential effects of CD20+ B cells and PD-L1+ immune cells on pathologic complete response and outcome: comparison between inflammatory breast cancer and locally advanced breast cancer patients.4
346548262021CD20 positive CD8 T cells are a unique and transcriptionally-distinct subset of T cells with distinct transmigration properties.12
347431992021CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles.2
333524662021MS4A1 expression and function in T cells in the colorectal cancer tumor microenvironment.17
345427732021Differential effects of CD20+ B cells and PD-L1+ immune cells on pathologic complete response and outcome: comparison between inflammatory breast cancer and locally advanced breast cancer patients.4
346548262021CD20 positive CD8 T cells are a unique and transcriptionally-distinct subset of T cells with distinct transmigration properties.12
347431992021CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles.2
316823182020CD20-positive primary nasal peripheral T-cell lymphoma: An analysis of one case and review of the literature.1
320562022020STIM1 knock-down decreases the affinity of obinutuzumab for CD20 by altering CD20 localization to Triton-soluble membrane.1
320796802020Structure of CD20 in complex with the therapeutic monoclonal antibody rituximab.71

Citation

Dessen P

MS4A1 (membrane spanning 4-domains A1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45648/img/gene-fusions-explorer/gene-explorer/