SIRPA (signal regulatory protein alpha)

2007-02-01  

Identity

HGNC
SIRPA
LOCATION
20p13
LOCUSID
140885
ALIAS
BIT,CD172A,MFR,MYD-1,P84,PTPNS1,SHPS1,SIRP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 140885
MIM: 602461
HGNC: 9662
Ensembl: ENSG00000198053

Variants:

dbSNP: 140885
ClinVar: 140885
TCGA: ENSG00000198053
COSMIC: SIRPA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198053ENST00000356025P78324
ENSG00000198053ENST00000358771P78324
ENSG00000198053ENST00000400068P78324
ENSG00000198053ENST00000622179P78324

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
Cell-Cell communicationREACTOMER-HSA-1500931
Signal regulatory protein (SIRP) family interactionsREACTOMER-HSA-391160
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil

References

Pubmed IDYearTitleCitations
382455852024Surfactant protein D prevents mucin overproduction in airway goblet cells via SIRPα.1
382455852024Surfactant protein D prevents mucin overproduction in airway goblet cells via SIRPα.1
357370882023Clinical significance of signal regulatory protein alpha and T cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibition motif domain expression in undifferentiated pleomorphic sarcoma.2
366415152023Clinical Significance of Signal Regulatory Protein Alpha (SIRPα) Expression in Hepatocellular Carcinoma.0
367913242023Thrombospondin-1, CD47, and SIRPα display cell-specific molecular signatures in human islets and pancreata.3
376604782023A mAb to SIRPα downregulates the priming of naive CD4 + T cell in Primary immune thrombocytopenia.0
378444482023SIRP-alpha-IL-6 axis induces immunosuppressive macrophages in non-small-cell lung cancer.0
382794882023Anti-tumor effect of PTEN and its effect on inhibition of the bone tumor through the CD47-SIRPα signaling pathway.0
357370882023Clinical significance of signal regulatory protein alpha and T cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibition motif domain expression in undifferentiated pleomorphic sarcoma.2
366415152023Clinical Significance of Signal Regulatory Protein Alpha (SIRPα) Expression in Hepatocellular Carcinoma.0
367913242023Thrombospondin-1, CD47, and SIRPα display cell-specific molecular signatures in human islets and pancreata.3
376604782023A mAb to SIRPα downregulates the priming of naive CD4 + T cell in Primary immune thrombocytopenia.0
378444482023SIRP-alpha-IL-6 axis induces immunosuppressive macrophages in non-small-cell lung cancer.0
382794882023Anti-tumor effect of PTEN and its effect on inhibition of the bone tumor through the CD47-SIRPα signaling pathway.0
349408292022Loss of myeloid cell-specific SIRPα, but not CD47, attenuates inflammation and suppresses atherosclerosis.13

Citation

Dessen P

SIRPA (signal regulatory protein alpha)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45658/teaching-explorer/deep-insight-explorer/