PGRMC1 (progesterone receptor membrane component 1)

2007-02-01  

Identity

HGNC
PGRMC1
LOCATION
Xq24
LOCUSID
10857
ALIAS
Dap1,HPR6.6,IZA,MPR
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10857
MIM: 300435
HGNC: 16090
Ensembl: ENSG00000101856

Variants:

dbSNP: 10857
ClinVar: 10857
TCGA: ENSG00000101856
COSMIC: PGRMC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101856ENST00000217971O00264
ENSG00000101856ENST00000217971Q6IB11
ENSG00000101856ENST00000535419O00264

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
379659402024Downregulation of PGRMC1 accelerates differentiation and fusion of a human trophoblast cell line.1
383082542024Progesterone-induced progesterone receptor membrane component 1 rise-to-decline changes are essential for decidualization.0
384894952024Defining Requirements for Heme Binding in PGRMC1 and Identifying Key Elements that Influence Protein Dimerization.1
385557472024Progesterone-mediated remodeling of the maternal-fetal interface by a PGRMC1-dependent mechanism.0
379659402024Downregulation of PGRMC1 accelerates differentiation and fusion of a human trophoblast cell line.1
383082542024Progesterone-induced progesterone receptor membrane component 1 rise-to-decline changes are essential for decidualization.0
384894952024Defining Requirements for Heme Binding in PGRMC1 and Identifying Key Elements that Influence Protein Dimerization.1
385557472024Progesterone-mediated remodeling of the maternal-fetal interface by a PGRMC1-dependent mechanism.0
367248202023PGRMC1 promotes triple-negative breast cancer cell growth via suppressing ferroptosis.5
373856162023Expression of PGRMC1 in patients with polycystic ovary syndrome and its molecular mechanism for regulating ovarian granulosa cell apoptosis and glucolipid metabolism.0
378666352023Progesterone receptor membrane component 1 facilitates Ca(2+) signal amplification between endosomes and the endoplasmic reticulum.2
378873422023Progesterone Receptor Membrane Component 1 (PGRMC1) Modulates Tumour Progression, the Immune Microenvironment and the Response to Therapy in Glioblastoma.2
379732162023Regulatory action of PGRMC1 on cyclic AMP-mediated COX2 expression in human endometrial cells.0
367248202023PGRMC1 promotes triple-negative breast cancer cell growth via suppressing ferroptosis.5
373856162023Expression of PGRMC1 in patients with polycystic ovary syndrome and its molecular mechanism for regulating ovarian granulosa cell apoptosis and glucolipid metabolism.0

Citation

Dessen P

PGRMC1 (progesterone receptor membrane component 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45676