Identity
HGNC
LOCATION
Xq24
LOCUSID
ALIAS
Dap1,HPR6.6,IZA,MPR
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 10857
MIM: 300435
HGNC: 16090
Ensembl: ENSG00000101856
Variants:
dbSNP: 10857
ClinVar: 10857
TCGA: ENSG00000101856
COSMIC: PGRMC1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000101856 | ENST00000217971 | O00264 |
| ENSG00000101856 | ENST00000217971 | Q6IB11 |
| ENSG00000101856 | ENST00000535419 | O00264 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Immune System | REACTOME | R-HSA-168256 |
| Innate Immune System | REACTOME | R-HSA-168249 |
| Neutrophil degranulation | REACTOME | R-HSA-6798695 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37965940 | 2024 | Downregulation of PGRMC1 accelerates differentiation and fusion of a human trophoblast cell line. | 1 |
| 38308254 | 2024 | Progesterone-induced progesterone receptor membrane component 1 rise-to-decline changes are essential for decidualization. | 0 |
| 38489495 | 2024 | Defining Requirements for Heme Binding in PGRMC1 and Identifying Key Elements that Influence Protein Dimerization. | 1 |
| 38555747 | 2024 | Progesterone-mediated remodeling of the maternal-fetal interface by a PGRMC1-dependent mechanism. | 0 |
| 37965940 | 2024 | Downregulation of PGRMC1 accelerates differentiation and fusion of a human trophoblast cell line. | 1 |
| 38308254 | 2024 | Progesterone-induced progesterone receptor membrane component 1 rise-to-decline changes are essential for decidualization. | 0 |
| 38489495 | 2024 | Defining Requirements for Heme Binding in PGRMC1 and Identifying Key Elements that Influence Protein Dimerization. | 1 |
| 38555747 | 2024 | Progesterone-mediated remodeling of the maternal-fetal interface by a PGRMC1-dependent mechanism. | 0 |
| 36724820 | 2023 | PGRMC1 promotes triple-negative breast cancer cell growth via suppressing ferroptosis. | 5 |
| 37385616 | 2023 | Expression of PGRMC1 in patients with polycystic ovary syndrome and its molecular mechanism for regulating ovarian granulosa cell apoptosis and glucolipid metabolism. | 0 |
| 37866635 | 2023 | Progesterone receptor membrane component 1 facilitates Ca(2+) signal amplification between endosomes and the endoplasmic reticulum. | 2 |
| 37887342 | 2023 | Progesterone Receptor Membrane Component 1 (PGRMC1) Modulates Tumour Progression, the Immune Microenvironment and the Response to Therapy in Glioblastoma. | 2 |
| 37973216 | 2023 | Regulatory action of PGRMC1 on cyclic AMP-mediated COX2 expression in human endometrial cells. | 0 |
| 36724820 | 2023 | PGRMC1 promotes triple-negative breast cancer cell growth via suppressing ferroptosis. | 5 |
| 37385616 | 2023 | Expression of PGRMC1 in patients with polycystic ovary syndrome and its molecular mechanism for regulating ovarian granulosa cell apoptosis and glucolipid metabolism. | 0 |
Citation
Dessen P
PGRMC1 (progesterone receptor membrane component 1)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/45676/pgrmc1
