ZFP36 (ZFP36 ring finger protein)

2007-02-01  

Identity

HGNC
LOCATION
19q13.2
LOCUSID
ALIAS
G0S24,GOS24,NUP475,RNF162A,TIS11,TTP,zfp-36
FUSION GENES

Other Information

Locus ID:

NCBI: 7538
MIM: 190700
HGNC: 12862
Ensembl: ENSG00000128016

Variants:

dbSNP: 7538
ClinVar: 7538
TCGA: ENSG00000128016
COSMIC: ZFP36

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128016ENST00000594045M0R252
ENSG00000128016ENST00000594442M0QY76
ENSG00000128016ENST00000597629P26651

Expression (GTEx)

0
500
1000
1500
2000

Pathways

PathwaySourceExternal ID
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Gene ExpressionREACTOMER-HSA-74160
Regulation of mRNA stability by proteins that bind AU-rich elementsREACTOMER-HSA-450531
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNAREACTOMER-HSA-450513

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
383515962024Persistent infection with Porphyromonas gingivalis increases the tumorigenic potential of human immortalised oral epithelial cells through ZFP36 inhibition.1
383515962024Persistent infection with Porphyromonas gingivalis increases the tumorigenic potential of human immortalised oral epithelial cells through ZFP36 inhibition.1
364228402023Silencing lncRNA CDKN2B-AS1 Alleviates Childhood Asthma Progression Through Inhibiting ZFP36 Promoter Methylation and Promoting NR4A1 Expression.1
375871402023ZFP36 loss-mediated BARX1 stabilization promotes malignant phenotypes by transactivating master oncogenes in NSCLC.1
377070562023ZIKV induction of tristetraprolin in endothelial and Sertoli cells post-transcriptionally inhibits IFNβ/λ expression and promotes ZIKV persistence.1
364228402023Silencing lncRNA CDKN2B-AS1 Alleviates Childhood Asthma Progression Through Inhibiting ZFP36 Promoter Methylation and Promoting NR4A1 Expression.1
375871402023ZFP36 loss-mediated BARX1 stabilization promotes malignant phenotypes by transactivating master oncogenes in NSCLC.1
377070562023ZIKV induction of tristetraprolin in endothelial and Sertoli cells post-transcriptionally inhibits IFNβ/λ expression and promotes ZIKV persistence.1
343330172022ZFP36 Family Members Regulate the Proinflammatory Features of Psoriatic Dermal Fibroblasts.10
355385432022Identification of ISG15 and ZFP36 as novel hypoxia- and immune-related gene signatures contributing to a new perspective for the treatment of prostate cancer by bioinformatics and experimental verification.9
361302712022Intrinsically disordered regions of tristetraprolin and DCP2 directly interact to mediate decay of ARE-mRNA.0
364765952022Assessing the expression of two post-transcriptional BDNF regulators, TTP and miR-16 in the peripheral blood of patients with Schizophrenia.1
343330172022ZFP36 Family Members Regulate the Proinflammatory Features of Psoriatic Dermal Fibroblasts.10
355385432022Identification of ISG15 and ZFP36 as novel hypoxia- and immune-related gene signatures contributing to a new perspective for the treatment of prostate cancer by bioinformatics and experimental verification.9
361302712022Intrinsically disordered regions of tristetraprolin and DCP2 directly interact to mediate decay of ARE-mRNA.0

Citation

Dessen P

ZFP36 (ZFP36 ring finger protein)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45691/zfp36