PBK (PDZ binding kinase)

2007-02-01  

Identity

HGNC
PBK
LOCATION
8p21.1
LOCUSID
55872
ALIAS
CT84,HEL164,Nori-3,SPK,TOPK
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55872
MIM: 611210
HGNC: 18282
Ensembl: ENSG00000168078

Variants:

dbSNP: 55872
ClinVar: 55872
TCGA: ENSG00000168078
COSMIC: PBK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168078ENST00000301905Q96KB5
ENSG00000168078ENST00000301905V9HWH0
ENSG00000168078ENST00000521226E5RFX4
ENSG00000168078ENST00000522944Q96KB5
ENSG00000168078ENST00000524266E5RIE1

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381315172024TOPK promotes the development of psoriasis and worenine alleviates psoriasiform dermatitis by inhibiting TOPK activity.1
381315172024TOPK promotes the development of psoriasis and worenine alleviates psoriasiform dermatitis by inhibiting TOPK activity.1
368073092023PDZ-binding kinase aggravates pancreatic neuroendocrine neoplasm progression by activating the AKT/mTOR pathway.0
371487022023TOPK inhibits TNF-α-induced granulosa cell apoptosis via regulation of SIRT1/p53.2
372266422023KRAS(G12C) mutation-induced TOPK overexpression contributes to tumour progression in non-small cell lung cancer.2
373284642023TOPK promotes the growth of esophageal cancer in vitro and in vivo by enhancing YB1/eEF1A1 signal pathway.2
368073092023PDZ-binding kinase aggravates pancreatic neuroendocrine neoplasm progression by activating the AKT/mTOR pathway.0
371487022023TOPK inhibits TNF-α-induced granulosa cell apoptosis via regulation of SIRT1/p53.2
372266422023KRAS(G12C) mutation-induced TOPK overexpression contributes to tumour progression in non-small cell lung cancer.2
373284642023TOPK promotes the growth of esophageal cancer in vitro and in vivo by enhancing YB1/eEF1A1 signal pathway.2
350371442022The role of T-LAK cell-originated protein kinase in targeted cancer therapy.3
351397682022Acetylshikonin suppresses diffuse large B-Cell Lymphoma cell growth by targeting the T-lymphokine-activated killer cell-originated protein kinase signalling pathway.0
355461432022TOPK/PBK is phosphorylated by ERK2 at serine 32, promotes tumorigenesis and is involved in sorafenib resistance in RCC.9
355933072022Identification of PBK as a hub gene and potential therapeutic target for medulloblastoma.3
357564882022TOPK Affects Autophagy of Skin Squamous Cell Carcinoma by Regulating NF-KB Pathway through HDAC1.0

Citation

Dessen P

PBK (PDZ binding kinase)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45697