PIP (prolactin induced protein)

2007-02-01 Affiliation

Identity

HGNC

PIP

LOCATION

7q34

LOCUSID

5304

ALIAS

GCDFP-15,GCDFP15,GPIP4

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5304
MIM: 176720
HGNC: 8993
Ensembl: ENSG00000159763

Variants:

dbSNP: 5304
ClinVar: 5304
TCGA: ENSG00000159763
COSMIC: PIP

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000159763	ENST00000291009	P12273

Expression (GTEx)

5000

10000

15000

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
Miscellaneous transport and binding events	REACTOME	R-HSA-5223345

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
37085653	2023	Prolactin-induced protein (PIP) increases the sensitivity of breast cancer cells to drug-induced apoptosis.	1
37085653	2023	Prolactin-induced protein (PIP) increases the sensitivity of breast cancer cells to drug-induced apoptosis.	1
33509033	2021	Peripheral immune tolerance by prolactin-induced protein originated from human invariant natural killer T cells.	1
34440877	2021	Unraveling Human AQP5-PIP Molecular Interaction and Effect on AQP5 Salivary Glands Localization in SS Patients.	0
33509033	2021	Peripheral immune tolerance by prolactin-induced protein originated from human invariant natural killer T cells.	1
34440877	2021	Unraveling Human AQP5-PIP Molecular Interaction and Effect on AQP5 Salivary Glands Localization in SS Patients.	0
29084054	2019	Columnar Cell Lesion and Apocrine Hyperplasia of the Breast: Is There a Common Origin? The Role of Prolactin-induced Protein.	7
29629946	2019	Efficacy of GATA3 Versus BRST2 for the Identification of Metastatic Breast Carcinoma in the Upper GI Tract: Which Performs Better?	1
30393162	2019	Prolactin-Induced Protein is a novel biomarker for Keratoconus.	25
31468711	2019	Histological hallmarks and role of Slug/PIP axis in pulmonary hypertension secondary to pulmonary fibrosis.	11
29084054	2019	Columnar Cell Lesion and Apocrine Hyperplasia of the Breast: Is There a Common Origin? The Role of Prolactin-induced Protein.	7
29629946	2019	Efficacy of GATA3 Versus BRST2 for the Identification of Metastatic Breast Carcinoma in the Upper GI Tract: Which Performs Better?	1
30393162	2019	Prolactin-Induced Protein is a novel biomarker for Keratoconus.	25
31468711	2019	Histological hallmarks and role of Slug/PIP axis in pulmonary hypertension secondary to pulmonary fibrosis.	11
29340880	2018	GATA-3 is superior to GCDFP-15 and mammaglobin to identify primary and metastatic breast cancer.	25

Citation

Dessen P

PIP (prolactin induced protein)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45702