MTNR1A (melatonin receptor 1A)

2007-02-01  

Identity

HGNC
MTNR1A
LOCATION
4q35.2
LOCUSID
4543
ALIAS
MEL-1A-R,MT1

Other Information

Locus ID:

NCBI: 4543
MIM: 600665
HGNC: 7463
Ensembl: ENSG00000168412

Variants:

dbSNP: 4543
ClinVar: 4543
TCGA: ENSG00000168412
COSMIC: MTNR1A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168412ENST00000307161P48039

Expression (GTEx)

0
1
2
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Circadian entrainmentKEGGhsa04713
Circadian entrainmentKEGGko04713
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

References

Pubmed IDYearTitleCitations
385497652024Rs4862705 in the melatonin receptor 1A gene is associated with renal function decline in type 1 diabetes individuals.0
385497652024Rs4862705 in the melatonin receptor 1A gene is associated with renal function decline in type 1 diabetes individuals.0
368926702023MTNR1A and MTNR1B Gene Variants of the Melatonin Receptor and Arterial Stiffness in Persons without Arterial Hypertension.2
371382672023Association of rotating night shift work, CLOCK, MTNR1A, MTNR1B genes polymorphisms and their interactions with type 2 diabetes among steelworkers: a case-control study.0
372597522023Melatonin receptor 1A (MTNR1A) gene linkage and association to type 2 diabetes in Italian families.4
368926702023MTNR1A and MTNR1B Gene Variants of the Melatonin Receptor and Arterial Stiffness in Persons without Arterial Hypertension.2
371382672023Association of rotating night shift work, CLOCK, MTNR1A, MTNR1B genes polymorphisms and their interactions with type 2 diabetes among steelworkers: a case-control study.0
372597522023Melatonin receptor 1A (MTNR1A) gene linkage and association to type 2 diabetes in Italian families.4
350751272022Structural basis of the ligand binding and signaling mechanism of melatonin receptors.13
358892222022Melatonin Reverses the Warburg-Type Metabolism and Reduces Mitochondrial Membrane Potential of Ovarian Cancer Cells Independent of MT1 Receptor Activation.14
362441292022Association between genetic polymorphisms in the melatonin receptor type 1 A gene and sleep bruxism.0
350751272022Structural basis of the ligand binding and signaling mechanism of melatonin receptors.13
358892222022Melatonin Reverses the Warburg-Type Metabolism and Reduces Mitochondrial Membrane Potential of Ovarian Cancer Cells Independent of MT1 Receptor Activation.14
362441292022Association between genetic polymorphisms in the melatonin receptor type 1 A gene and sleep bruxism.0
327306622021The MTNR1A mRNA is stabilized by the cytoplasmic hnRNPL in renal tubular cells.3

Citation

Dessen P

MTNR1A (melatonin receptor 1A)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45706