SIGMAR1 (sigma non-opioid intracellular receptor 1)

2007-02-01  

Identity

HGNC
SIGMAR1
LOCATION
9p13.3
LOCUSID
10280
ALIAS
ALS16,DSMA2,OPRS1,SIG-1R,SR-BP,SR-BP1,SRBP,hSigmaR1,sigma1R
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10280
MIM: 601978
HGNC: 8157
Ensembl: ENSG00000147955

Variants:

dbSNP: 10280
ClinVar: 10280
TCGA: ENSG00000147955
COSMIC: SIGMAR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147955ENST00000277010Q99720
ENSG00000147955ENST00000353468Q99720
ENSG00000147955ENST00000378892Q5T1J1
ENSG00000147955ENST00000477726Q99720
ENSG00000147955ENST00000477726A2A3U5

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
386215042024Unraveling the CLCC1 interactome: Impact of the Asp25Glu variant and its interaction with SigmaR1 at the Mitochondrial-Associated ER Membrane (MAM).0
386215042024Unraveling the CLCC1 interactome: Impact of the Asp25Glu variant and its interaction with SigmaR1 at the Mitochondrial-Associated ER Membrane (MAM).0
358714912023TRPA1 modulation by Sigma-1 receptor prevents oxaliplatin-induced painful peripheral neuropathy.8
363520932023An investigation of Sigma-1 receptor expression and ligand-induced endoplasmic reticulum stress in breast cancer.2
367682992023Overview of Sigma-1R Subcellular Specific Biological Functions and Role in Neuroprotection.7
367683232023Sigma-1 Receptor Signaling: In Search of New Therapeutic Alternatives for Cardiovascular and Renal Diseases.2
370473382023Investigation of the Entry Pathway and Molecular Nature of σ1 Receptor Ligands.1
371754732023SIGMAR1 Confers Innate Resilience against Neurodegeneration.4
371996652023Sig1R activates extracellular matrix-induced bladder cancer cell proliferation and angiogenesis by combing β-integrin.1
375113892023The Sigma-1 Receptor Is a Novel Target for Improving Cold Preservation in Rodent Kidney Transplants.0
358714912023TRPA1 modulation by Sigma-1 receptor prevents oxaliplatin-induced painful peripheral neuropathy.8
363520932023An investigation of Sigma-1 receptor expression and ligand-induced endoplasmic reticulum stress in breast cancer.2
367682992023Overview of Sigma-1R Subcellular Specific Biological Functions and Role in Neuroprotection.7
367683232023Sigma-1 Receptor Signaling: In Search of New Therapeutic Alternatives for Cardiovascular and Renal Diseases.2
370473382023Investigation of the Entry Pathway and Molecular Nature of σ1 Receptor Ligands.1

Citation

Dessen P

SIGMAR1 (sigma non-opioid intracellular receptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45709/js/lib/img/haematological-explorer/