MICB (MHC class I polypeptide-related sequence B)

2007-02-01  

Identity

HGNC
MICB
LOCATION
6p21.33
LOCUSID
4277
ALIAS
PERB11.2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4277
MIM: 602436
HGNC: 7091
Ensembl: ENSG00000204516
IMGT/GENE-DB:

Variants:

dbSNP: 4277
ClinVar: 4277
TCGA: ENSG00000204516
COSMIC: MICB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000204516ENST00000252229X6R344
ENSG00000204516ENST00000399150Q29980
ENSG00000204516ENST00000538442F5H7Q8

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Natural killer cell mediated cytotoxicityKEGGko04650
Natural killer cell mediated cytotoxicityKEGGhsa04650
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164749390peginterferon alfa-2aChemicalClinicalAnnotationassociatedPD
PA164784024peginterferon alfa-2bChemicalClinicalAnnotationassociatedPD
PA446863Hepatitis C, ChronicDiseaseClinicalAnnotationassociatedPD
PA451241ribavirinChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
378788202024MICB Genomic Variant Is Associated with NKG2D-mediated Acute Lung Injury and Death.1
382058782024Linc-ROR inhibits NK cell-killing activity by promoting RXRA ubiquitination and reducing MICB expression in gastric cancer patients.0
378788202024MICB Genomic Variant Is Associated with NKG2D-mediated Acute Lung Injury and Death.1
382058782024Linc-ROR inhibits NK cell-killing activity by promoting RXRA ubiquitination and reducing MICB expression in gastric cancer patients.0
368980462023Clinical Significance of Plasma Soluble MICB in Children With EBV-associated Hemophagocytic Lymphohistiocytosis.0
369588492023Associations between MICA and MICB Genetic Variants, Protein Levels, and Colorectal Cancer: Atherosclerosis Risk in Communities (ARIC).2
368980462023Clinical Significance of Plasma Soluble MICB in Children With EBV-associated Hemophagocytic Lymphohistiocytosis.0
369588492023Associations between MICA and MICB Genetic Variants, Protein Levels, and Colorectal Cancer: Atherosclerosis Risk in Communities (ARIC).2
355257112022HLA class I chain-related MICA and MICB genes polymorphism in healthy individuals from the Bulgarian population.0
355257112022HLA class I chain-related MICA and MICB genes polymorphism in healthy individuals from the Bulgarian population.0
338356012021Associations of high-resolution-typing-defined MICA and MICB polymorphisms, and the levels of soluble MICA and MICB with Oral Squamous Cell Carcinoma in Bulgarian patients.1
340124322021Increased Concentrations of Circulating Soluble MHC Class I-Related Chain A (sMICA) and sMICB and Modulation of Plasma Membrane MICA Expression: Potential Mechanisms and Correlation With Natural Killer Cell Activity in Systemic Lupus Erythematosus.7
343724952021Intracellular Sequestration of the NKG2D Ligand MIC B by Species F Adenovirus.2
344823622021Immunomodulatory effect of NEDD8-activating enzyme inhibition in Multiple Myeloma: upregulation of NKG2D ligands and sensitization to Natural Killer cell recognition.8
338356012021Associations of high-resolution-typing-defined MICA and MICB polymorphisms, and the levels of soluble MICA and MICB with Oral Squamous Cell Carcinoma in Bulgarian patients.1

Citation

Dessen P

MICB (MHC class I polypeptide-related sequence B)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45710