Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 54577
MIM: 606432
HGNC: 12539
Ensembl: ENSG00000244122
Variants:
dbSNP: 54577
ClinVar: 54577
TCGA: ENSG00000244122
COSMIC: UGT1A7
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000244122 | ENST00000373426 | Q9HAW7 |
| ENSG00000244122 | ENST00000373426 | Q5DSZ7 |
| ENSG00000244122 | ENST00000485022 | H0Y8D7 |
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA10251 | atazanavir | Chemical | ClinicalAnnotation | associated | PD | 17058217 | |
| PA131285527 | oxaliplatin | Chemical | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 23963147 | |
| PA164748728 | mycophenolic acid | Chemical | Pathway | associated | 24220207 | ||
| PA165958521 | febuxostat | Chemical | ClinicalAnnotation | associated | PD | 27798726 | |
| PA166115442 | s 1 (combination) | Chemical | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 23963147 | |
| PA420 | UGT1A1 | Gene | VipGene | associated | 11037804, 11434514, 12019197, 12181437, 12969965, 14647407, 15179404, 1651156, 17058217, 17728214, 18004212, 18349289, 18466101, 18491077, 18518849, 19364970, 19390945, 19794410, 19852077, 19997083, 20562211, 8467709, 10381366 | ||
| PA443937 | Drug Toxicity | Disease | VariantAnnotation | not associated | PD | ||
| PA444065 | Epilepsy | Disease | ClinicalAnnotation | associated | PK | PD | 15761113, 21806385, 27900402, 28763744 |
| PA444318 | Gout | Disease | ClinicalAnnotation | associated | PD | 27798726 | |
| PA444511 | Hyperbilirubinemia | Disease | ClinicalAnnotation | associated | PD | 17058217 | |
| PA445601 | Osteosarcoma | Disease | ClinicalAnnotation | associated | PK | 29791011 | |
| PA445629 | Seizures | Disease | ClinicalAnnotation | associated | PD | 27900402 | |
| PA446051 | Vomiting | Disease | VariantAnnotation | associated | PD | ||
| PA446108 | Colorectal Neoplasms | Disease | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 23963147 | |
| PA447216 | Schizophrenia | Disease | ClinicalAnnotation | associated | PD | ||
| PA447230 | HIV | Disease | ClinicalAnnotation | associated | PD | 17058217 | |
| PA448320 | allopurinol | Chemical | ClinicalAnnotation | associated | PD | 27798726 | |
| PA450085 | irinotecan | Chemical | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 23963147 | |
| PA450428 | methotrexate | Chemical | ClinicalAnnotation | associated | PK | 29791011 | |
| PA450732 | oxcarbazepine | Chemical | ClinicalAnnotation | associated | PD | 27900402 | |
| PA451257 | risperidone | Chemical | ClinicalAnnotation | associated | PD | ||
| PA451260 | ritonavir | Chemical | ClinicalAnnotation | associated | PD | 17058217 | |
| PA451846 | valproic acid | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PK | PD | 15761113, 21806385, 28763744 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 33105931 | 2020 | [Gene mutation pattern of Gilbert's syndrome combined with viral hepatitis and its relationship with the exploration of clinical data]. | 0 |
| 33105931 | 2020 | [Gene mutation pattern of Gilbert's syndrome combined with viral hepatitis and its relationship with the exploration of clinical data]. | 0 |
| 31132973 | 2019 | Interethnic Variations of UGT1A1 and UGT1A7 Polymorphisms in the Jordanian Population. | 3 |
| 31132973 | 2019 | Interethnic Variations of UGT1A1 and UGT1A7 Polymorphisms in the Jordanian Population. | 3 |
| 25899702 | 2016 | Genetic polymorphisms in UDP-glucuronosyltransferase 1A6 and 1A7 and the risk for benign Warthin's tumors of the parotid gland. | 0 |
| 25899702 | 2016 | Genetic polymorphisms in UDP-glucuronosyltransferase 1A6 and 1A7 and the risk for benign Warthin's tumors of the parotid gland. | 0 |
| 25743847 | 2015 | Increased UGT1A3 and UGT1A7 expression is associated with pancreatic cancer. | 8 |
| 25743847 | 2015 | Increased UGT1A3 and UGT1A7 expression is associated with pancreatic cancer. | 8 |
| 24255116 | 2014 | Alteration of the function of the UDP-glucuronosyltransferase 1A subfamily by cytochrome P450 3A4: different susceptibility for UGT isoforms and UGT1A1/7 variants. | 16 |
| 24453052 | 2014 | Differences in UGT1A1, UGT1A7, and UGT1A9 polymorphisms between Uzbek and Japanese populations. | 9 |
| 24255116 | 2014 | Alteration of the function of the UDP-glucuronosyltransferase 1A subfamily by cytochrome P450 3A4: different susceptibility for UGT isoforms and UGT1A1/7 variants. | 16 |
| 24453052 | 2014 | Differences in UGT1A1, UGT1A7, and UGT1A9 polymorphisms between Uzbek and Japanese populations. | 9 |
| 23789755 | 2013 | [Influence of genetic polymorphisms in UGT1A1, UGT1A7 and UGT1A9 on the pharmacokynetics of irinotecan, SN-38 and SN-38G]. | 4 |
| 23789755 | 2013 | [Influence of genetic polymorphisms in UGT1A1, UGT1A7 and UGT1A9 on the pharmacokynetics of irinotecan, SN-38 and SN-38G]. | 4 |
| 22402308 | 2012 | The association between UGT1A7 polymorphism and cancer risk: a meta-analysis. | 3 |
Citation
Dessen P
UGT1A7 (UDP glucuronosyltransferase family 1 member A7)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/45712/ugt1a7
