TLR2 (toll like receptor 2)

2007-02-01  

Identity

HGNC
TLR2
LOCATION
4q31.3
LOCUSID
7097
ALIAS
CD282,TIL4

Other Information

Locus ID:

NCBI: 7097
MIM: 603028
HGNC: 11848
Ensembl: ENSG00000137462

Variants:

dbSNP: 7097
ClinVar: 7097
TCGA: ENSG00000137462
COSMIC: TLR2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137462ENST00000260010O60603
ENSG00000137462ENST00000260010A0A0S2Z4S4
ENSG00000137462ENST00000642580O60603
ENSG00000137462ENST00000642580A0A0S2Z4S4
ENSG00000137462ENST00000642700O60603
ENSG00000137462ENST00000642700A0A0S2Z4S4
ENSG00000137462ENST00000643087A0A0S2Z4L7
ENSG00000137462ENST00000643501A0A2R8Y7R7
ENSG00000137462ENST00000646219A0A2R8YHF6
ENSG00000137462ENST00000646900A0A2R8Y4N9

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Toll-like receptor signaling pathwayKEGGko04620
Toll-like receptor signaling pathwayKEGGhsa04620
LeishmaniasisKEGGko05140
LeishmaniasisKEGGhsa05140
Chagas disease (American trypanosomiasis)KEGGko05142
Chagas disease (American trypanosomiasis)KEGGhsa05142
MalariaKEGGko05144
MalariaKEGGhsa05144
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
AmoebiasisKEGGko05146
AmoebiasisKEGGhsa05146
ToxoplasmosisKEGGko05145
ToxoplasmosisKEGGhsa05145
Rheumatoid arthritisKEGGko05323
Rheumatoid arthritisKEGGhsa05323
MeaslesKEGGko05162
MeaslesKEGGhsa05162
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
LegionellosisKEGGko05134
LegionellosisKEGGhsa05134
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Hepatitis BKEGGhsa05161
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Inflammatory bowel disease (IBD)KEGGhsa05321
Inflammatory bowel disease (IBD)KEGGko05321
Toll-like receptor signalingKEGGhsa_M00686
Toll-like receptor signalingKEGGM00686
DiseaseREACTOMER-HSA-1643685
Diseases of Immune SystemREACTOMER-HSA-5260271
Diseases associated with the TLR signaling cascadeREACTOMER-HSA-5602358
IRAK4 deficiency (TLR2/4)REACTOMER-HSA-5603041
MyD88 deficiency (TLR2/4)REACTOMER-HSA-5602498
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing-Cross presentationREACTOMER-HSA-1236975
ER-Phagosome pathwayREACTOMER-HSA-1236974
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Toll Like Receptor 4 (TLR4) CascadeREACTOMER-HSA-166016
Activated TLR4 signallingREACTOMER-HSA-166054
MyD88:Mal cascade initiated on plasma membraneREACTOMER-HSA-166058
Toll Like Receptor 2 (TLR2) CascadeREACTOMER-HSA-181438
Toll Like Receptor TLR1:TLR2 CascadeREACTOMER-HSA-168179
Toll Like Receptor TLR6:TLR2 CascadeREACTOMER-HSA-168188
DefensinsREACTOMER-HSA-1461973
Beta defensinsREACTOMER-HSA-1461957
Regulation of TLR by endogenous ligandREACTOMER-HSA-5686938
Antimicrobial peptidesREACTOMER-HSA-6803157
Neutrophil degranulationREACTOMER-HSA-6798695

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164713366Tumor necrosis factor alpha (TNF-alpha) inhibitorsChemicalClinicalAnnotationassociatedPD24776844, 28696418
PA443750Colitis, UlcerativeDiseaseClinicalAnnotationassociatedPD24776844
PA443815Crohn DiseaseDiseaseClinicalAnnotationassociatedPD24776844
PA445451PsoriasisDiseaseClinicalAnnotationassociatedPD24776844, 28696418
PA446116Inflammatory Bowel DiseasesDiseaseClinicalAnnotationassociatedPD24776844, 28696418

References

Pubmed IDYearTitleCitations
375851742024Synonymous mutations in TLR2 and TLR9 genes decrease COPD susceptibility in the Chinese Han population.1
377181982024Association between genetic variants of TLR2, TLR4, TLR9 and schizophrenia.0
379770662024The expression of Nrf2 and TLRs in ear effusion in children with different types of otitis media and their relationship with inflammatory factors.0
380627332024Age-Associated KLF9 Enhances the Inflammatory Response of Alveolar Macrophages Via Regulating TLR2 Expression.0
382514232024Extracellular vesicles from periodontal pathogens regulate hepatic steatosis via Toll-like receptor 2 and plasminogen activator inhibitor-1.2
382963902024Correlation of polymorphism in Toll-Like Receptor (TLR1 and TLR2) genes with susceptibility of pulmonary tuberculosis in Doda region of India.0
383447582024P. gingivalis-Induced TLR2 Interactome Analysis Reveals Association with PARP9.0
383686392024p53 suppresses the inflammatory response following respiratory syncytial virus infection by inhibiting TLR2.0
383942592024miR-328-3p targets TLR2 to ameliorate oxygen-glucose deprivation injury and neutrophil extracellular trap formation in HUVECs via inhibition of the NF-κB signaling pathway.0
384193962024Exploring the Impact of TLR-2 Signaling on miRNA Dysregulation in Intervertebral Disc Degeneration.0
384208132024Analysis of TLR2 in Primary Endocrine Resistant of Breast Cancer.0
384921052024Expression of TLR2, IL-1β, and IL-10 Genes as a Possible Factor of Successful or Pathological Aging in Nonagenarians.0
386489012024TRPV3 promotes sebocyte inflammation via transcriptional modulating TLR2 in acne.0
387972882024Identification of toll-like receptor 2 as a key regulator of neuronal apoptosis in vascular dementia by bioinformatics analysis and experimental validation.0
388689692024Strong association of TLR2 and TLR3 polymorphisms with keratoacanthoma and common warts: a case-control study.0

Citation

Dessen P

TLR2 (toll like receptor 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45714