GALR2 (galanin receptor 2)

2007-02-01  

Identity

HGNC
LOCATION
17q25.1
LOCUSID
ALIAS
GAL2-R,GALNR2,GALR-2

Other Information

Locus ID:

NCBI: 8811
MIM: 603691
HGNC: 4133
Ensembl: ENSG00000182687

Variants:

dbSNP: 8811
ClinVar: 8811
TCGA: ENSG00000182687
COSMIC: GALR2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000182687ENST00000329003O43603

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
10

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
354090942022Galanin Receptors (GalR1, GalR2, and GalR3) Expression in Colorectal Cancer Tissue and Correlations to the Overall Survival and Poor Prognosis of CRC Patients.6
359139792022Structure of the human galanin receptor 2 bound to galanin and Gq reveals the basis of ligand specificity and how binding affects the G-protein interface.0
354090942022Galanin Receptors (GalR1, GalR2, and GalR3) Expression in Colorectal Cancer Tissue and Correlations to the Overall Survival and Poor Prognosis of CRC Patients.6
359139792022Structure of the human galanin receptor 2 bound to galanin and Gq reveals the basis of ligand specificity and how binding affects the G-protein interface.0
322313932020Exploring the molecular structures that confer ligand selectivity for galanin type II and III receptors.0
322313932020Exploring the molecular structures that confer ligand selectivity for galanin type II and III receptors.0
306164682019Galanin expression is down-regulated in patients with gastric cancer.8
306164682019Galanin expression is down-regulated in patients with gastric cancer.8
276858432017Site-specific methylation patterns of the GAL and GALR1/2 genes in head and neck cancer: Potential utility as biomarkers for prognosis.19
276858432017Site-specific methylation patterns of the GAL and GALR1/2 genes in head and neck cancer: Potential utility as biomarkers for prognosis.19
265721462016Epigenetic inactivation of galanin and GALR1/2 is associated with early recurrence in head and neck cancer.15
265721462016Epigenetic inactivation of galanin and GALR1/2 is associated with early recurrence in head and neck cancer.15
241224502014Tumor suppressor activity and inactivation of galanin receptor type 2 by aberrant promoter methylation in head and neck cancer.19
241681122014Novel anti-tumor mechanism of galanin receptor type 2 in head and neck squamous cell carcinoma cells.9
245172312014Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III.74

Citation

Dessen P

GALR2 (galanin receptor 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45716/galr2