GPX2 (glutathione peroxidase 2)

2007-02-01  

Identity

HGNC
GPX2
LOCATION
14q23.3
LOCUSID
2877
ALIAS
GI-GPx,GPRP,GPRP-2,GPx-2,GPx-GI,GSHPX-GI,GSHPx-2

Other Information

Locus ID:

NCBI: 2877
MIM: 138319
HGNC: 4554
Ensembl: ENSG00000176153

Variants:

dbSNP: 2877
ClinVar: 2877
TCGA: ENSG00000176153
COSMIC: GPX2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000176153ENST00000389614P18283
ENSG00000176153ENST00000553522G3V323
ENSG00000176153ENST00000557049H0YJK8
ENSG00000176153ENST00000557323G3V4J6
ENSG00000176153ENST00000612794A0A087WTS0

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glutathione metabolismKEGGko00480
Arachidonic acid metabolismKEGGko00590
Glutathione metabolismKEGGhsa00480
Arachidonic acid metabolismKEGGhsa00590
Thyroid hormone synthesisKEGGhsa04918
Thyroid hormone synthesisKEGGko04918
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Metabolic GenesREACTOMER-HSA-5628897
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Arachidonic acid metabolismREACTOMER-HSA-2142753
Synthesis of 5-eicosatetraenoic acidsREACTOMER-HSA-2142688
Synthesis of 15-eicosatetraenoic acid derivativesREACTOMER-HSA-2142770
Synthesis of 12-eicosatetraenoic acid derivativesREACTOMER-HSA-2142712
Cellular responses to stressREACTOMER-HSA-2262752
Detoxification of Reactive Oxygen SpeciesREACTOMER-HSA-3299685

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
367962002023Glutathione peroxidase 2: A key factor in the development of microsatellite instability in colon cancer.1
371380312023Glutathione peroxidase 2 knockdown suppresses gastric cancer progression and metastasis via regulation of kynurenine metabolism.4
377434832023ACVRL1 drives resistance to multitarget tyrosine kinase inhibitors in colorectal cancer by promoting USP15-mediated GPX2 stabilization.0
378107782023Long non-coding RNA NMRAL2P promotes glycolysis and reduces ROS in head and neck tumors by interacting with the ENO1 protein and promoting GPX2 transcription.0
367962002023Glutathione peroxidase 2: A key factor in the development of microsatellite instability in colon cancer.1
371380312023Glutathione peroxidase 2 knockdown suppresses gastric cancer progression and metastasis via regulation of kynurenine metabolism.4
377434832023ACVRL1 drives resistance to multitarget tyrosine kinase inhibitors in colorectal cancer by promoting USP15-mediated GPX2 stabilization.0
378107782023Long non-coding RNA NMRAL2P promotes glycolysis and reduces ROS in head and neck tumors by interacting with the ENO1 protein and promoting GPX2 transcription.0
349540792022Iron-mediated epigenetic activation of NRF2 targets.11
351939552022Redox signaling by glutathione peroxidase 2 links vascular modulation to metabolic plasticity of breast cancer.22
362222982022Glutathione peroxidase 2 overexpression promotes malignant progression and cisplatin resistance of KRAS‑mutated lung cancer cells.8
349540792022Iron-mediated epigenetic activation of NRF2 targets.11
351939552022Redox signaling by glutathione peroxidase 2 links vascular modulation to metabolic plasticity of breast cancer.22
362222982022Glutathione peroxidase 2 overexpression promotes malignant progression and cisplatin resistance of KRAS‑mutated lung cancer cells.8
336228682021Reduced Expression Level of GPX2 in T1 Bladder Cancer and its Role in Early-phase Invasion of Bladder Cancer.4

Citation

Dessen P

GPX2 (glutathione peroxidase 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45718