PTPRO (protein tyrosine phosphatase receptor type O)

2007-02-01  

Identity

HGNC
PTPRO
LOCATION
12p12.3
LOCUSID
5800
ALIAS
GLEPP1,NPHS6,PTP-OC,PTP-U2,PTPROT,PTPU2,R-PTP-O
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5800
MIM: 600579
HGNC: 9678
Ensembl: ENSG00000151490

Variants:

dbSNP: 5800
ClinVar: 5800
TCGA: ENSG00000151490
COSMIC: PTPRO

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000151490ENST00000281171Q16827
ENSG00000151490ENST00000348962Q16827
ENSG00000151490ENST00000442921Q16827
ENSG00000151490ENST00000442921A0A024RAS9
ENSG00000151490ENST00000445537Q16827
ENSG00000151490ENST00000445537A0A024RAS9
ENSG00000151490ENST00000535311H0YH11
ENSG00000151490ENST00000535322H0YH60
ENSG00000151490ENST00000542557Q16827
ENSG00000151490ENST00000542557A0A024RAS0
ENSG00000151490ENST00000543886Q16827
ENSG00000151490ENST00000544244Q16827
ENSG00000151490ENST00000544244A0A024RAS0
ENSG00000151490ENST00000674388A0A024RAS9

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381825702024Protein tyrosine phosphatase PTPRO represses lung adenocarcinoma progression by inducing mitochondria-dependent apoptosis and restraining tumor metastasis.0
381825702024Protein tyrosine phosphatase PTPRO represses lung adenocarcinoma progression by inducing mitochondria-dependent apoptosis and restraining tumor metastasis.0
355276652022PTPRO activates TLR4/NF-κB signaling to intensify lipopolysaccharide-induced pneumonia cell injury.3
360033822022PTPRO-related CD8(+) T-cell signatures predict prognosis and immunotherapy response in patients with breast cancer.7
355276652022PTPRO activates TLR4/NF-κB signaling to intensify lipopolysaccharide-induced pneumonia cell injury.3
360033822022PTPRO-related CD8(+) T-cell signatures predict prognosis and immunotherapy response in patients with breast cancer.7
340072442021MiR-6869-5p Induces M2 Polarization by Regulating PTPRO in Gestational Diabetes Mellitus.7
347193072021Protein tyrosine phosphatase receptor type O (PTPRO) knockdown enhances the proliferative, invasive and angiogenic activities of trophoblast cells by suppressing ER resident protein 44 (ERp44) expression in preeclampsia.1
340072442021MiR-6869-5p Induces M2 Polarization by Regulating PTPRO in Gestational Diabetes Mellitus.7
347193072021Protein tyrosine phosphatase receptor type O (PTPRO) knockdown enhances the proliferative, invasive and angiogenic activities of trophoblast cells by suppressing ER resident protein 44 (ERp44) expression in preeclampsia.1
314522372020PTPRO exaggerates inflammation in ulcerative colitis through TLR4/NF-κB pathway.9
325810552020IL-6 promotes PD-L1 expression in monocytes and macrophages by decreasing protein tyrosine phosphatase receptor type O expression in human hepatocellular carcinoma.74
314522372020PTPRO exaggerates inflammation in ulcerative colitis through TLR4/NF-κB pathway.9
325810552020IL-6 promotes PD-L1 expression in monocytes and macrophages by decreasing protein tyrosine phosphatase receptor type O expression in human hepatocellular carcinoma.74
304439492019MiRNA-548c-5p downregulates inflammatory response in preeclampsia via targeting PTPRO.26

Citation

Dessen P

PTPRO (protein tyrosine phosphatase receptor type O)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45721