BRS3 (bombesin receptor subtype 3)

2007-02-01  

Identity

HGNC
BRS3
LOCATION
Xq26.3
LOCUSID
680
ALIAS
BB3,BB3R,BBR3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 680
MIM: 300107
HGNC: 1113
Ensembl: ENSG00000102239

Variants:

dbSNP: 680
ClinVar: 680
TCGA: ENSG00000102239
COSMIC: BRS3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102239ENST00000370648P32247

Expression (GTEx)

0
1
2
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

References

Pubmed IDYearTitleCitations
350321942022Agonist-induced extracellular vesicles contribute to the transfer of functional bombesin receptor-subtype 3 to recipient cells.0
350321942022Agonist-induced extracellular vesicles contribute to the transfer of functional bombesin receptor-subtype 3 to recipient cells.0
294016132018Receptor-specific crosstalk between prostanoid E receptor 3 and bombesin receptor subtype 3.3
294024942018Activation of bombesin receptor Subtype-3 by [D-Tyr(6),β-Ala(11),Phe(13),Nle(14)]bombesin(6-14) increased glucose uptake and lipogenesis in human and rat adipocytes.0
294103202018A possible new target in lung-cancer cells: The orphan receptor, bombesin receptor subtype-3.16
294016132018Receptor-specific crosstalk between prostanoid E receptor 3 and bombesin receptor subtype 3.3
294024942018Activation of bombesin receptor Subtype-3 by [D-Tyr(6),β-Ala(11),Phe(13),Nle(14)]bombesin(6-14) increased glucose uptake and lipogenesis in human and rat adipocytes.0
294103202018A possible new target in lung-cancer cells: The orphan receptor, bombesin receptor subtype-3.16
260209402015The Nutrient-Responsive Hormone CCHamide-2 Controls Growth by Regulating Insulin-like Peptides in the Brain of Drosophila melanogaster.80
260209402015The Nutrient-Responsive Hormone CCHamide-2 Controls Growth by Regulating Insulin-like Peptides in the Brain of Drosophila melanogaster.80
242205022014Human BRS-3 receptor: functions/role in cell signaling pathways and glucose metabolism in obese or diabetic myocytes.6
243263632014RC-3095, a gastrin-releasing peptide receptor antagonist, synergizes with gemcitabine to inhibit the growth of human pancreatic cancer CFPAC-1 in vitro and in vivo.1
252410332014Gene expression accurately distinguishes liver metastases of small bowel and pancreas neuroendocrine tumors.21
242205022014Human BRS-3 receptor: functions/role in cell signaling pathways and glucose metabolism in obese or diabetic myocytes.6
243263632014RC-3095, a gastrin-releasing peptide receptor antagonist, synergizes with gemcitabine to inhibit the growth of human pancreatic cancer CFPAC-1 in vitro and in vivo.1

Citation

Dessen P

BRS3 (bombesin receptor subtype 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45724/css/template-nav.css