Identity
HGNC
LOCATION
19p13.3
LOCUSID
ALIAS
GPx-4,GSHPx-4,MCSP,PHGPx,SMDS,snGPx,snPHGPx
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2879
MIM: 138322
HGNC: 4556
Ensembl: ENSG00000167468
Variants:
dbSNP: 2879
ClinVar: 2879
TCGA: ENSG00000167468
COSMIC: GPX4
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36828120 | 2024 | FUNDC1 interacts with GPx4 to govern hepatic ferroptosis and fibrotic injury through a mitophagy-dependent manner. | 13 |
| 37344692 | 2024 | Circular RNA 0016142 Knockdown Induces Ferroptosis in Hepatocellular Carcinoma Cells via Modulation of the MicroRNA-188-3p/Glutathione Peroxidase 4 Axis. | 2 |
| 37690733 | 2024 | Ancient dormant virus remnant ERVW-1 drives ferroptosis via degradation of GPX4 and SLC3A2 in schizophrenia. | 2 |
| 37860888 | 2024 | Ubiquitin-specific peptidase 10 attenuates the ferroptosis to promote thyroid cancer malignancy by facilitating GPX4 via elevating SIRT6. | 1 |
| 37968154 | 2024 | Targeting GPX4-mediated Ferroptosis Alleviates Liver Steatosis in a Rat Model of Total Parenteral Nutrition. | 0 |
| 38123365 | 2024 | Ferroptosis-related gene glutathione peroxidase 4 promotes reprogramming of glucose metabolism via Akt-mTOR axis in intrahepatic cholangiocarcinoma. | 0 |
| 38176476 | 2024 | P21 resists ferroptosis in osteoarthritic chondrocytes by regulating GPX4 protein stability. | 2 |
| 38182643 | 2024 | Selenoprotein P expression in glioblastoma as a regulator of ferroptosis sensitivity: preservation of GPX4 via the cycling-selenium storage. | 0 |
| 38228715 | 2024 | GSTM3 enhances radiosensitivity of nasopharyngeal carcinoma by promoting radiation-induced ferroptosis through USP14/FASN axis and GPX4. | 0 |
| 38244593 | 2024 | Circ0060467 sponges miR-6805 to promote hepatocellular carcinoma progression through regulating AIFM2 and GPX4 expression. | 1 |
| 38250761 | 2024 | GPX4 inhibits apoptosis of thyroid cancer cells through regulating the FKBP8/Bcl-2 axis. | 0 |
| 38252317 | 2024 | Selenium-SelK-GPX4 axis protects nucleus pulposus cells against mechanical overloading-induced ferroptosis and attenuates senescence of intervertebral disc. | 2 |
| 38342812 | 2024 | Expression and Significance of BCCIP and Glutathione Peroxidase 4 in Clear Cell Renal Cell Carcinoma. | 0 |
| 38429265 | 2024 | Depletion of the N(6)-Methyladenosine (m6A) reader protein IGF2BP3 induces ferroptosis in glioma by modulating the expression of GPX4. | 0 |
| 38441967 | 2024 | CD8+ T cells sustain antitumor response by mediating crosstalk between adenosine A2A receptor and glutathione/GPX4. | 1 |
Citation
Dessen P
GPX4 (glutathione peroxidase 4)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/45734/gpx4
