RGS7 (regulator of G protein signaling 7)

2007-02-01  

Identity

HGNC
RGS7
LOCATION
1q43
LOCUSID
6000
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6000
MIM: 602517
HGNC: 10003
Ensembl: ENSG00000182901

Variants:

dbSNP: 6000
ClinVar: 6000
TCGA: ENSG00000182901
COSMIC: RGS7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000182901ENST00000348120P49802
ENSG00000182901ENST00000366563P49802
ENSG00000182901ENST00000366564P49802
ENSG00000182901ENST00000366565P49802
ENSG00000182901ENST00000440928Q5T3H5

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Protein foldingREACTOMER-HSA-391251
Chaperonin-mediated protein foldingREACTOMER-HSA-390466
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta foldingREACTOMER-HSA-6814122

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
365747072023A RGS7-CaMKII complex drives myocyte-intrinsic and myocyte-extrinsic mechanisms of chemotherapy-induced cardiotoxicity.4
369992762023RGS7 silence protects palmitic acid-induced pancreatic β-cell injury by inactivating the chemokine signaling pathway.1
375897512023RGS7 balances acetylation/de-acetylation of p65 to control chemotherapy-dependent cardiac inflammation.2
365747072023A RGS7-CaMKII complex drives myocyte-intrinsic and myocyte-extrinsic mechanisms of chemotherapy-induced cardiotoxicity.4
369992762023RGS7 silence protects palmitic acid-induced pancreatic β-cell injury by inactivating the chemokine signaling pathway.1
375897512023RGS7 balances acetylation/de-acetylation of p65 to control chemotherapy-dependent cardiac inflammation.2
347931982022Cryo-EM structure of human GPR158 receptor coupled to the RGS7-Gβ5 signaling complex.14
347931982022Cryo-EM structure of human GPR158 receptor coupled to the RGS7-Gβ5 signaling complex.14
348154012021Structure of the class C orphan GPCR GPR158 in complex with RGS7-Gβ5.8
348154012021Structure of the class C orphan GPCR GPR158 in complex with RGS7-Gβ5.8
293305212018RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells.10
305402502018Structural organization of a major neuronal G protein regulator, the RGS7-Gβ5-R7BP complex.13
293305212018RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells.10
305402502018Structural organization of a major neuronal G protein regulator, the RGS7-Gβ5-R7BP complex.13
284321242017Regulation of neurite morphogenesis by interaction between R7 regulator of G protein signaling complexes and G protein subunit Gα(13).6

Citation

Dessen P

RGS7 (regulator of G protein signaling 7)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45750