Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5205
MIM: 602397
HGNC: 3706
Ensembl: ENSG00000081923
Variants:
dbSNP: 5205
ClinVar: 5205
TCGA: ENSG00000081923
COSMIC: ATP8B1
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Transmembrane transport of small molecules | REACTOME | R-HSA-382551 |
| Ion channel transport | REACTOME | R-HSA-983712 |
| Ion transport by P-type ATPases | REACTOME | R-HSA-936837 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36794287 | 2023 | ATP8B1: A prognostic prostate cancer biomarker identified via genetic analysis. | 1 |
| 37980352 | 2023 | Activation and substrate specificity of the human P4-ATPase ATP8B1. | 2 |
| 36794287 | 2023 | ATP8B1: A prognostic prostate cancer biomarker identified via genetic analysis. | 1 |
| 37980352 | 2023 | Activation and substrate specificity of the human P4-ATPase ATP8B1. | 2 |
| 34942279 | 2022 | Heterozygous mutations of ATP8B1, ABCB11 and ABCB4 cause mild forms of Progressive Familial Intrahepatic Cholestasis in a pediatric cohort. | 2 |
| 35349344 | 2022 | Structural insights into the activation of autoinhibited human lipid flippase ATP8B1 upon substrate binding. | 12 |
| 35416773 | 2022 | Autoinhibition and regulation by phosphoinositides of ATP8B1, a human lipid flippase associated with intrahepatic cholestatic disorders. | 14 |
| 35585825 | 2022 | Modulation of ATP8B1 Gene Expression in Colorectal Cancer Cells Suggest its Role as a Tumor Suppressor. | 1 |
| 35894240 | 2022 | Clinical phenotype of adult-onset liver disease in patients with variants in ABCB4, ABCB11, and ATP8B1. | 7 |
| 36293199 | 2022 | ATP8B1 Deficiency Results in Elevated Mitochondrial Phosphatidylethanolamine Levels and Increased Mitochondrial Oxidative Phosphorylation in Human Hepatoma Cells. | 2 |
| 34942279 | 2022 | Heterozygous mutations of ATP8B1, ABCB11 and ABCB4 cause mild forms of Progressive Familial Intrahepatic Cholestasis in a pediatric cohort. | 2 |
| 35349344 | 2022 | Structural insights into the activation of autoinhibited human lipid flippase ATP8B1 upon substrate binding. | 12 |
| 35416773 | 2022 | Autoinhibition and regulation by phosphoinositides of ATP8B1, a human lipid flippase associated with intrahepatic cholestatic disorders. | 14 |
| 35585825 | 2022 | Modulation of ATP8B1 Gene Expression in Colorectal Cancer Cells Suggest its Role as a Tumor Suppressor. | 1 |
| 35894240 | 2022 | Clinical phenotype of adult-onset liver disease in patients with variants in ABCB4, ABCB11, and ATP8B1. | 7 |
Citation
Dessen P
ATP8B1 (ATPase phospholipid transporting 8B1)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/45755/atp8b1
