Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 6470
MIM: 182144
HGNC: 10850
Ensembl: ENSG00000176974
Variants:
dbSNP: 6470
ClinVar: 6470
TCGA: ENSG00000176974
COSMIC: SHMT1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA128406956 | fluorouracil | Chemical | ClinicalAnnotation | associated | PD | 22044939 | |
| PA130232992 | bevacizumab | Chemical | ClinicalAnnotation | associated | PD | 22044939 | |
| PA443434 | Arthritis, Rheumatoid | Disease | ClinicalAnnotation | associated | PD | 18322994, 20386493 | |
| PA446108 | Colorectal Neoplasms | Disease | ClinicalAnnotation | associated | PD | 22044939 | |
| PA446155 | Precursor Cell Lymphoblastic Leukemia-Lymphoma | Disease | ClinicalAnnotation | associated | PK | PD | 15797993, 18368069, 22838948 |
| PA450085 | irinotecan | Chemical | ClinicalAnnotation | associated | PD | 22044939 | |
| PA450198 | leucovorin | Chemical | ClinicalAnnotation | associated | PD | 22044939 | |
| PA450428 | methotrexate | Chemical | ClinicalAnnotation | associated | PK | PD | 15797993, 18322994, 18368069, 20386493, 22838948 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36417280 | 2023 | Serine hydroxymethyltransferase 1 promotes low-grade glioma progression by activating mTORC1 signaling. | 1 |
| 36417280 | 2023 | Serine hydroxymethyltransferase 1 promotes low-grade glioma progression by activating mTORC1 signaling. | 1 |
| 33974584 | 2022 | Association Between SHMT1 rs1979277 Polymorphism and Risk of Acute Lymphoblastic Leukemia: A Systematic Review and Meta-analysis. | 1 |
| 34341479 | 2022 | Targeting serine hydroxymethyltransferases 1 and 2 for T-cell acute lymphoblastic leukemia therapy. | 20 |
| 33974584 | 2022 | Association Between SHMT1 rs1979277 Polymorphism and Risk of Acute Lymphoblastic Leukemia: A Systematic Review and Meta-analysis. | 1 |
| 34341479 | 2022 | Targeting serine hydroxymethyltransferases 1 and 2 for T-cell acute lymphoblastic leukemia therapy. | 20 |
| 33259775 | 2021 | The association between serine hydroxymethyl transferase 1 gene hypermethylation and ischemic stroke. | 3 |
| 33326752 | 2021 | Tumor Reliance on Cytosolic versus Mitochondrial One-Carbon Flux Depends on Folate Availability. | 23 |
| 33259775 | 2021 | The association between serine hydroxymethyl transferase 1 gene hypermethylation and ischemic stroke. | 3 |
| 33326752 | 2021 | Tumor Reliance on Cytosolic versus Mitochondrial One-Carbon Flux Depends on Folate Availability. | 23 |
| 31713293 | 2020 | A SHMT1 variant decreases the risk of nonsyndromic cleft lip with or without cleft palate in Chile. | 4 |
| 31713293 | 2020 | A SHMT1 variant decreases the risk of nonsyndromic cleft lip with or without cleft palate in Chile. | 4 |
| 30411815 | 2019 | Serine hydroxymethyltransferase 1 promoter hypermethylation increases the risk of essential hypertension. | 5 |
| 30456721 | 2019 | Association of SHMT1, MAZ, ERG, and L3MBTL3 Gene Polymorphisms with Susceptibility to Multiple Sclerosis. | 4 |
| 30809670 | 2019 | The moonlighting RNA-binding activity of cytosolic serine hydroxymethyltransferase contributes to control compartmentalization of serine metabolism. | 21 |
Citation
Dessen P
SHMT1 (serine hydroxymethyltransferase 1)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/45764/shmt1
