EDN1 (endothelin 1)

2007-02-01 Affiliation

Identity

HGNC

EDN1

LOCATION

6p24.1

LOCUSID

1906

ALIAS

ARCND3,ET1,HDLCQ7,PPET1,QME

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1906
MIM: 131240
HGNC: 3176
Ensembl: ENSG00000078401

Variants:

dbSNP: 1906
ClinVar: 1906
TCGA: ENSG00000078401
COSMIC: EDN1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000078401	ENST00000379375	P05305
ENSG00000078401	ENST00000379375	Q6FH53

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Melanogenesis	KEGG	ko04916
Melanogenesis	KEGG	hsa04916
HIF-1 signaling pathway	KEGG	hsa04066
TNF signaling pathway	KEGG	hsa04668
TNF signaling pathway	KEGG	ko04668
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Peptide ligand-binding receptors	REACTOME	R-HSA-375276
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (q) signalling events	REACTOME	R-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907
AGE-RAGE signaling pathway in diabetic complications	KEGG	ko04933
AGE-RAGE signaling pathway in diabetic complications	KEGG	hsa04933
Fluid shear stress and atherosclerosis	KEGG	ko05418
Fluid shear stress and atherosclerosis	KEGG	hsa05418

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA130232992	bevacizumab	Chemical	ClinicalAnnotation	associated	PD	27139155
PA162356187	muraglitazar	Chemical	ClinicalAnnotation	associated	PD	18794727
PA443560	Breast Neoplasms	Disease	ClinicalAnnotation	associated	PD	27139155
PA443886	Diabetes Mellitus	Disease	ClinicalAnnotation	associated	PD	18794727
PA443994	Edema	Disease	ClinicalAnnotation	associated	PD	18794727
PA444528	Hyperlipidemias	Disease	ClinicalAnnotation	associated	PD	18794727
PA447288	Essential hypertension	Disease	ClinicalAnnotation	associated	PD	15188945
PA448499	atenolol	Chemical	ClinicalAnnotation	associated	PD	15188945
PA450084	irbesartan	Chemical	ClinicalAnnotation	associated	PD	15188945

References

Pubmed ID	Year	Title	Citations
38860875	2024	Microarray analysis demonstrates up-regulation of the endothelin-1 gene with compensatory down-regulation of the ETA receptor gene in human portal vein.	0
38874661	2024	Diagnostic potential of endothelin-1 in peri-implant diseases: a cross-sectional study.	0
38884602	2024	The endothelin-1-driven tumor-stroma feed-forward loops in high-grade serous ovarian cancer.	0
38860875	2024	Microarray analysis demonstrates up-regulation of the endothelin-1 gene with compensatory down-regulation of the ETA receptor gene in human portal vein.	0
38874661	2024	Diagnostic potential of endothelin-1 in peri-implant diseases: a cross-sectional study.	0
38884602	2024	The endothelin-1-driven tumor-stroma feed-forward loops in high-grade serous ovarian cancer.	0
36279697	2023	Endothelin-1 gene polymorphism (G8002A) and endothelial monocyte-activating polypeptide II: Role in vascular dysfunction in pediatric patients with β-thalassemia major.	0
36475746	2023	Epstein-Barr Virus Regulates Endothelin-1 Expression through the ERK/FOXO1 Pathway in EBV-Associated Gastric Cancer.	3
36675028	2023	Endothelial Dysfunction Drives CRTd Outcome at 1-Year Follow-Up: A Novel Role as Biomarker for miR-130a-5p.	1
36796652	2023	Hypoxic glioma cell-secreted exosomal circ101491 promotes the progression of glioma by regulating miR-125b-5p/EDN1.	5
36829141	2023	Potential role of eNOS and EDN-1 gene polymorphisms in the development and progression of retinopathy of prematurity.	0
36901906	2023	Endothelin-1 Induces Cell Proliferation and Myofibroblast Differentiation through the ET(A)R/G(αq)/ERK Signaling Pathway in Human Cardiac Fibroblasts.	4
36966225	2023	Association of blood pressure variability with Endothelin-1 by menopause status among Black women: findings from the Jackson Heart Study.	0
36977700	2023	Vascular parameters and endothelin-1 measurements in glaucoma patients with low- and high-tension optic disc hemorrhages.	3
37036487	2023	Plasma endothelin-1 may predict bevacizumab-induced proteinuria in patients with colorectal cancer.	1

Citation

Dessen P

EDN1 (endothelin 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45765