AGT (angiotensinogen)

2007-02-01  

Identity

HGNC
AGT
LOCATION
1q42.2
LOCUSID
183
ALIAS
ANHU,SERPINA8,hFLT1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 183
MIM: 106150
HGNC: 333
Ensembl: ENSG00000135744

Variants:

dbSNP: 183
ClinVar: 183
TCGA: ENSG00000135744
COSMIC: AGT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135744ENST00000366667P01019
ENSG00000135744ENST00000366667B0ZBE2

Expression (GTEx)

0
500
1000
1500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Renin-angiotensin systemKEGGko04614
Renin-angiotensin systemKEGGhsa04614
Renin secretionKEGGhsa04924
Renin secretionKEGGko04924
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Metabolism of Angiotensinogen to AngiotensinsREACTOMER-HSA-2022377
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164712308Ace Inhibitors, PlainChemicalClinicalAnnotationassociatedPD14643574
PA164712462Antiinflammatory agents, non-steroidsChemicalClinicalAnnotationassociatedPD20538124
PA165108401Acute coronary syndromeDiseaseClinicalAnnotationassociatedPD20538124
PA443796Coronary Artery DiseaseDiseaseClinicalAnnotationassociatedPD11849656
PA444552HypertensionDiseaseClinicalAnnotationassociatedPD11593098, 14643574, 14700505, 15614026, 17261659, 25143324
PA446479Hypertrophy, Left VentricularDiseaseClinicalAnnotationassociatedPD11593098, 14700505, 15614026
PA448388amlodipineChemicalClinicalAnnotationassociatedPD
PA448497aspirinChemicalClinicalAnnotationassociatedPD20824505
PA448499atenololChemicalClinicalAnnotationassociatedPD11593098, 14700505
PA448561benazeprilChemicalClinicalAnnotationassociatedPD17261659, 25143324
PA448970chlorthalidoneChemicalClinicalAnnotationassociatedPD
PA450084irbesartanChemicalClinicalAnnotationassociatedPD11593098, 14700505, 15614026
PA450242lisinoprilChemicalClinicalAnnotationassociatedPD
PA451205quinaprilChemicalClinicalAnnotationassociatedPD11849656
PA452640imidaprilChemicalClinicalAnnotationassociatedPD25143324

References

Pubmed IDYearTitleCitations
379091692024Deficiency of Complement C3a and C5a receptors Does Not Prevent Angiotensin II-Induced Hypertension and Hypertensive End-Organ Damage.1
380614702024The role of angiotensin II activation of yes-associated protein/PDZ-binding motif signaling in hypertensive cardiac and vascular remodeling.0
381057552024OTUD6A in tubular epithelial cells mediates angiotensin II-induced kidney injury by targeting STAT3.0
382651732024Correlation of single nucleotide polymorphisms in the AGT gene with susceptibility to systemic lupus erythematosus in Northeast China.0
382793132024Interplay of Angiotensin Peptides, Vasopressin, and Insulin in the Heart: Experimental and Clinical Evidence of Altered Interactions in Obesity and Diabetes Mellitus.0
383804502024Genetic Variations of Angiotensinogen, Angiotensin Converting Enzyme, and Angiotensin Type 1 Receptor with the Risk of Pulmonary Tuberculosis.0
384897042024Association of rs5051 and rs699 polymorphisms in angiotensinogen with coronary artery disease in Iranian population: A case-control study.0
384923252024Role of Angiotensin II in Non-Alcoholic Steatosis Development.0
386227202024The role of the brain renin-angiotensin system in Parkinson´s disease.1
379091692024Deficiency of Complement C3a and C5a receptors Does Not Prevent Angiotensin II-Induced Hypertension and Hypertensive End-Organ Damage.1
380614702024The role of angiotensin II activation of yes-associated protein/PDZ-binding motif signaling in hypertensive cardiac and vascular remodeling.0
381057552024OTUD6A in tubular epithelial cells mediates angiotensin II-induced kidney injury by targeting STAT3.0
382651732024Correlation of single nucleotide polymorphisms in the AGT gene with susceptibility to systemic lupus erythematosus in Northeast China.0
382793132024Interplay of Angiotensin Peptides, Vasopressin, and Insulin in the Heart: Experimental and Clinical Evidence of Altered Interactions in Obesity and Diabetes Mellitus.0
383804502024Genetic Variations of Angiotensinogen, Angiotensin Converting Enzyme, and Angiotensin Type 1 Receptor with the Risk of Pulmonary Tuberculosis.0

Citation

Dessen P

AGT (angiotensinogen)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45772