UBTF (upstream binding transcription factor)

2007-02-01  

Identity

HGNC
UBTF
LOCATION
17q21.31
LOCUSID
7343
ALIAS
CONDBA,NOR-90,UBF,UBF-1,UBF1,UBF2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7343
MIM: 600673
HGNC: 12511
Ensembl: ENSG00000108312

Variants:

dbSNP: 7343
ClinVar: 7343
TCGA: ENSG00000108312
COSMIC: UBTF

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108312ENST00000302904P17480
ENSG00000108312ENST00000343638P17480
ENSG00000108312ENST00000393606P17480
ENSG00000108312ENST00000436088P17480
ENSG00000108312ENST00000526094P17480
ENSG00000108312ENST00000527034E9PKP7
ENSG00000108312ENST00000529373E9PLT2
ENSG00000108312ENST00000529383P17480
ENSG00000108312ENST00000529947H0YDH7
ENSG00000108312ENST00000530828E9PMM2
ENSG00000108312ENST00000533177P17480

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase I, RNA Polymerase III, and Mitochondrial TranscriptionREACTOMER-HSA-504046
RNA Polymerase I TranscriptionREACTOMER-HSA-73864
RNA Polymerase I Promoter ClearanceREACTOMER-HSA-73854
RNA Polymerase I Promoter OpeningREACTOMER-HSA-73728
RNA Polymerase I Transcription InitiationREACTOMER-HSA-73762
RNA Polymerase I Promoter EscapeREACTOMER-HSA-73772
RNA Polymerase I Chain ElongationREACTOMER-HSA-73777
RNA Polymerase I Transcription TerminationREACTOMER-HSA-73863
Epigenetic regulation of gene expressionREACTOMER-HSA-212165
Negative epigenetic regulation of rRNA expressionREACTOMER-HSA-5250941
NoRC negatively regulates rRNA expressionREACTOMER-HSA-427413

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
364488762023UBTF-internal tandem duplication as a novel poor prognostic factor in pediatric acute myeloid leukemia.7
370856112023UBTF tandem duplications define a distinct subtype of adult de novo acute myeloid leukemia.6
372369682023UBTF tandem duplications are rare but recurrent alterations in adult AML and associated with younger age, myelodysplasia, and inferior outcome.4
376039672023FGF13A interacts with NPM1 and UBF and inhibits the invasion of bladder cancer cells.0
364488762023UBTF-internal tandem duplication as a novel poor prognostic factor in pediatric acute myeloid leukemia.7
370856112023UBTF tandem duplications define a distinct subtype of adult de novo acute myeloid leukemia.6
372369682023UBTF tandem duplications are rare but recurrent alterations in adult AML and associated with younger age, myelodysplasia, and inferior outcome.4
376039672023FGF13A interacts with NPM1 and UBF and inhibits the invasion of bladder cancer cells.0
351926842022Enhancer retargeting of CDX2 and UBTF::ATXN7L3 define a subtype of high-risk B-progenitor acute lymphoblastic leukemia.14
353163242022Concurrent CDX2 cis-deregulation and UBTF::ATXN7L3 fusion define a novel high-risk subtype of B-cell ALL.9
351926842022Enhancer retargeting of CDX2 and UBTF::ATXN7L3 define a subtype of high-risk B-progenitor acute lymphoblastic leukemia.14
353163242022Concurrent CDX2 cis-deregulation and UBTF::ATXN7L3 fusion define a novel high-risk subtype of B-cell ALL.9
323501152020Protein kinase Cι promotes UBF1-ECT2 binding on ribosomal DNA to drive rRNA synthesis and transformed growth of non-small-cell lung cancer cells.6
323501152020Protein kinase Cι promotes UBF1-ECT2 binding on ribosomal DNA to drive rRNA synthesis and transformed growth of non-small-cell lung cancer cells.6
312170762019Ectopically expressed pNO40 suppresses ribosomal RNA synthesis by inhibiting UBF-dependent transcription activation.6

Citation

Dessen P

UBTF (upstream binding transcription factor)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45793/js/css/lib/favicon/favicon-32x32.png