USP11 (ubiquitin specific peptidase 11)

2007-02-01  

Identity

HGNC
USP11
LOCATION
Xp11.3
LOCUSID
8237
ALIAS
UHX1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8237
MIM: 300050
HGNC: 12609
Ensembl: ENSG00000102226

Variants:

dbSNP: 8237
ClinVar: 8237
TCGA: ENSG00000102226
COSMIC: USP11

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102226ENST00000218348P51784
ENSG00000102226ENST00000377078Q5JXD3
ENSG00000102226ENST00000377080C9JBP8
ENSG00000102226ENST00000377107G5E9A6

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Protein foldingREACTOMER-HSA-391251
Chaperonin-mediated protein foldingREACTOMER-HSA-390466
Association of TriC/CCT with target proteins during biosynthesisREACTOMER-HSA-390471
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
379739522024USP11 potentiates HGF/AKT signaling and drives metastasis in hepatocellular carcinoma.0
380974452024Ubiquitin-specific peptidase 11 promotes development of keloid derived fibroblasts by de-ubiquitinating TGF-β receptorII.0
381828952024DLGAP5 triggers proliferation and metastasis of bladder cancer by stabilizing E2F1 via USP11.0
387223302024USP11 regulates proliferation and apoptosis of human spermatogonial stem cells via HOXC5-mediated canonical WNT/β-catenin signaling pathway.0
390528352024USP11 promotes prostate cancer progression by up-regulating AR and c-Myc activity.0
379739522024USP11 potentiates HGF/AKT signaling and drives metastasis in hepatocellular carcinoma.0
380974452024Ubiquitin-specific peptidase 11 promotes development of keloid derived fibroblasts by de-ubiquitinating TGF-β receptorII.0
381828952024DLGAP5 triggers proliferation and metastasis of bladder cancer by stabilizing E2F1 via USP11.0
387223302024USP11 regulates proliferation and apoptosis of human spermatogonial stem cells via HOXC5-mediated canonical WNT/β-catenin signaling pathway.0
390528352024USP11 promotes prostate cancer progression by up-regulating AR and c-Myc activity.0
368224522023USP11 plays a critical role in the onset and progression of acute graft-versus-host disease：Novel target for precision therapeutics.0
368977782023The lysine methyltransferase SMYD5 amplifies HIV-1 transcription and is post-transcriptionally upregulated by Tat and USP11.6
374147552023USP11-mediated LSH deubiquitination inhibits ferroptosis in colorectal cancer through epigenetic activation of CYP24A1.4
368224522023USP11 plays a critical role in the onset and progression of acute graft-versus-host disease：Novel target for precision therapeutics.0
368977782023The lysine methyltransferase SMYD5 amplifies HIV-1 transcription and is post-transcriptionally upregulated by Tat and USP11.6

Citation

Dessen P

USP11 (ubiquitin specific peptidase 11)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45825/meetings/css/cancer-prone-explorer/