SPHK1 (sphingosine kinase 1)

2007-02-01  

Identity

HGNC
SPHK1
LOCATION
17q25.1
LOCUSID
8877
ALIAS
SPHK
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8877
MIM: 603730
HGNC: 11240
Ensembl: ENSG00000176170

Variants:

dbSNP: 8877
ClinVar: 8877
TCGA: ENSG00000176170
COSMIC: SPHK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000176170ENST00000323374Q9NYA1
ENSG00000176170ENST00000392496Q9NYA1
ENSG00000176170ENST00000392496Q53ZR5
ENSG00000176170ENST00000545180Q9NYA1
ENSG00000176170ENST00000545180Q53ZR5
ENSG00000176170ENST00000588682K7EMA4
ENSG00000176170ENST00000590379K7EJ32
ENSG00000176170ENST00000590959Q9NYA1
ENSG00000176170ENST00000592299Q9NYA1
ENSG00000176170ENST00000592299Q53ZR5

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Sphingolipid metabolismKEGGko00600
Calcium signaling pathwayKEGGko04020
VEGF signaling pathwayKEGGko04370
Sphingolipid metabolismKEGGhsa00600
Calcium signaling pathwayKEGGhsa04020
VEGF signaling pathwayKEGGhsa04370
Fc gamma R-mediated phagocytosisKEGGko04666
Fc gamma R-mediated phagocytosisKEGGhsa04666
Metabolic pathwaysKEGGhsa01100
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Sphingosine degradationKEGGhsa_M00100
Sphingosine degradationKEGGM00100
Sphingolipid signaling pathwayKEGGhsa04071
Sphingolipid signaling pathwayKEGGko04071
Metabolism of proteinsREACTOMER-HSA-392499
Protein foldingREACTOMER-HSA-391251
Chaperonin-mediated protein foldingREACTOMER-HSA-390466
Association of TriC/CCT with target proteins during biosynthesisREACTOMER-HSA-390471
Signal TransductionREACTOMER-HSA-162582
Signaling by VEGFREACTOMER-HSA-194138
VEGFA-VEGFR2 PathwayREACTOMER-HSA-4420097
VEGFR2 mediated cell proliferationREACTOMER-HSA-5218921
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Sphingolipid metabolismREACTOMER-HSA-428157
Sphingolipid de novo biosynthesisREACTOMER-HSA-1660661
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072
Apelin signaling pathwayKEGGhsa04371

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381356962024SPHK1 potentiates colorectal cancer progression and metastasis via regulating autophagy mediated by TRAF6-induced ULK1 ubiquitination.1
382005822024Targeting the SphK1/S1P/PFKFB3 axis suppresses hepatocellular carcinoma progression by disrupting glycolytic energy supply that drives tumor angiogenesis.0
389535742024Interference with sphingosine kinase-1 reduces the hydrogen peroxide-induced oxidative stress damage in melanocytes through four and a half LIM domains 2.0
381356962024SPHK1 potentiates colorectal cancer progression and metastasis via regulating autophagy mediated by TRAF6-induced ULK1 ubiquitination.1
382005822024Targeting the SphK1/S1P/PFKFB3 axis suppresses hepatocellular carcinoma progression by disrupting glycolytic energy supply that drives tumor angiogenesis.0
389535742024Interference with sphingosine kinase-1 reduces the hydrogen peroxide-induced oxidative stress damage in melanocytes through four and a half LIM domains 2.0
363480172023DNA methylation status of the SPHK1 and LTB genes underlies the clinicopathological diversity of non-alcoholic steatohepatitis-related hepatocellular carcinomas.0
368231492023HOXC11 drives lung adenocarcinoma progression through transcriptional regulation of SPHK1.1
374676342023Sphingosine kinase 1 regulates lipid metabolism to promote progression of kidney renal clear cell carcinoma.0
375433622023Krüppel-like factor 12 regulates aging ovarian granulosa cell apoptosis by repressing SPHK1 transcription and sphingosine-1-phosphate (S1P) production.0
379444442023The role of SphK/S1P/S1PR signaling pathway in bone metabolism.0
363480172023DNA methylation status of the SPHK1 and LTB genes underlies the clinicopathological diversity of non-alcoholic steatohepatitis-related hepatocellular carcinomas.0
368231492023HOXC11 drives lung adenocarcinoma progression through transcriptional regulation of SPHK1.1
374676342023Sphingosine kinase 1 regulates lipid metabolism to promote progression of kidney renal clear cell carcinoma.0
375433622023Krüppel-like factor 12 regulates aging ovarian granulosa cell apoptosis by repressing SPHK1 transcription and sphingosine-1-phosphate (S1P) production.0

Citation

Dessen P

SPHK1 (sphingosine kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45829/js/js/lib/bootstrap.min.js