BRD7 (bromodomain containing 7)

2007-02-01  

Identity

HGNC
BRD7
LOCATION
16q12.1
LOCUSID
29117
ALIAS
BP75,CELTIX1,NAG4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 29117
MIM: 618489
HGNC: 14310
Ensembl: ENSG00000166164

Variants:

dbSNP: 29117
ClinVar: 29117
TCGA: ENSG00000166164
COSMIC: BRD7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166164ENST00000394688Q9NPI1
ENSG00000166164ENST00000394689Q9NPI1
ENSG00000166164ENST00000562383I3L0Y7
ENSG00000166164ENST00000569774I3L4V5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through AcetylationREACTOMER-HSA-6804758

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
364845042023Characterization of the Functional Interplay between the BRD7 and BRD9 Homologues in mSWI/SNF Complexes.0
367882092023BRD7 inhibits enhancer activity and expression of BIRC2 to suppress tumor growth and metastasis in nasopharyngeal carcinoma.7
373654292023Identification of BRD7 by whole-exome sequencing as a predictor for intermediate-stage hepatocellular carcinoma in patients undergoing TACE.0
364845042023Characterization of the Functional Interplay between the BRD7 and BRD9 Homologues in mSWI/SNF Complexes.0
367882092023BRD7 inhibits enhancer activity and expression of BIRC2 to suppress tumor growth and metastasis in nasopharyngeal carcinoma.7
373654292023Identification of BRD7 by whole-exome sequencing as a predictor for intermediate-stage hepatocellular carcinoma in patients undergoing TACE.0
359430532022BRD7 restrains TNF-α-induced proliferation and migration of airway smooth muscle cells by inhibiting notch signaling.1
364776552022LncRNA LENGA acts as a tumor suppressor in gastric cancer through BRD7/TP53 signaling.5
359430532022BRD7 restrains TNF-α-induced proliferation and migration of airway smooth muscle cells by inhibiting notch signaling.1
364776552022LncRNA LENGA acts as a tumor suppressor in gastric cancer through BRD7/TP53 signaling.5
340387452021Bromodomain-containing protein 7 regulates matrix metabolism and apoptosis in human nucleus pulposus cells through the BRD7-PI3K-YAP1 signaling axis.5
340387452021Bromodomain-containing protein 7 regulates matrix metabolism and apoptosis in human nucleus pulposus cells through the BRD7-PI3K-YAP1 signaling axis.5
319293482020Expression and subcellular localization of the bromodomain-containing protein 7 is a prognostic biomarker in breast cancer.0
319293482020Expression and subcellular localization of the bromodomain-containing protein 7 is a prognostic biomarker in breast cancer.0
305922932019Bromodomain‑containing protein 7 sensitizes breast cancer cells to paclitaxel by activating Bcl2‑antagonist/killer protein.11

Citation

Dessen P

BRD7 (bromodomain containing 7)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45835/gene-fusions-explorer/gene-explorer/js/web-card-_common.js