SLC9A3 (solute carrier family 9 member A3)

2007-02-01  

Identity

HGNC
SLC9A3
LOCATION
5p15.33
LOCUSID
6550
ALIAS
DIAR8,NHE-3,NHE3

Other Information

Locus ID:

NCBI: 6550
MIM: 182307
HGNC: 11073
Ensembl: ENSG00000066230

Variants:

dbSNP: 6550
ClinVar: 6550
TCGA: ENSG00000066230
COSMIC: SLC9A3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000066230ENST00000264938P48764
ENSG00000066230ENST00000514375P48764
ENSG00000066230ENST00000644203A0A2R8Y780

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Proximal tubule bicarbonate reclamationKEGGko04964
Proximal tubule bicarbonate reclamationKEGGhsa04964
Protein digestion and absorptionKEGGko04974
Protein digestion and absorptionKEGGhsa04974
Bile secretionKEGGko04976
Bile secretionKEGGhsa04976
Mineral absorptionKEGGko04978
Mineral absorptionKEGGhsa04978
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptidesREACTOMER-HSA-425393
Sodium/Proton exchangersREACTOMER-HSA-425986

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA27745ELF2GenePathwayassociated

References

Pubmed IDYearTitleCitations
380473022024Regulation of the intestinal Na(+)/H(+) exchanger NHE3 by AMP-activated kinase is dependent on phosphorylation of NHE3 at S555 and S563.1
380910652024Revisiting the association of sudden infant death syndrome (SIDS) with polymorphisms of NHE3 and IL13.0
384487272024New functions and roles of the Na(+)-H(+)-exchanger NHE3.0
380473022024Regulation of the intestinal Na(+)/H(+) exchanger NHE3 by AMP-activated kinase is dependent on phosphorylation of NHE3 at S555 and S563.1
380910652024Revisiting the association of sudden infant death syndrome (SIDS) with polymorphisms of NHE3 and IL13.0
384487272024New functions and roles of the Na(+)-H(+)-exchanger NHE3.0
348230642022Nedd4-2-dependent Ubiquitination Potentiates the Inhibition of Human NHE3 by Cholera Toxin and Enteropathogenic Escherichia coli.8
357193632022Intestine-Specific NHE3 Deletion in Adulthood Causes Microbial Dysbiosis.5
361899742022Downregulation of NHE-3 (SLC9A3) expression by MicroRNAs in intestinal epithelial cells.1
348230642022Nedd4-2-dependent Ubiquitination Potentiates the Inhibition of Human NHE3 by Cholera Toxin and Enteropathogenic Escherichia coli.8
357193632022Intestine-Specific NHE3 Deletion in Adulthood Causes Microbial Dysbiosis.5
361899742022Downregulation of NHE-3 (SLC9A3) expression by MicroRNAs in intestinal epithelial cells.1
325572272020Altered absorptive function in the gall bladder during cholesterol gallstone formation is associated with abnormal NHE3 complex formation.3
330954752020Ubiquitin-specific peptidase 7 (USP7) and USP10 mediate deubiquitination of human NHE3 regulating its expression and activity.8
325572272020Altered absorptive function in the gall bladder during cholesterol gallstone formation is associated with abnormal NHE3 complex formation.3

Citation

Dessen P

SLC9A3 (solute carrier family 9 member A3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45845