CCR4 (C-C motif chemokine receptor 4)

2007-02-01  

Identity

HGNC
CCR4
LOCATION
3p22.3
LOCUSID
1233
ALIAS
CC-CKR-4,CD194,CKR4,CMKBR4,ChemR13,HGCN:14099,K5-5

Other Information

Locus ID:

NCBI: 1233
MIM: 604836
HGNC: 1605
Ensembl: ENSG00000183813

Variants:

dbSNP: 1233
ClinVar: 1233
TCGA: ENSG00000183813
COSMIC: CCR4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183813ENST00000330953P51679
ENSG00000183813ENST00000330953A0N0Q1

Expression (GTEx)

0
1
2
3
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Chemokine receptors bind chemokinesREACTOMER-HSA-380108
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
370175292023Contributions of Ccr4 and Gcn2 to the Translational Response of C. neoformans to Host-Relevant Stressors and Integrated Stress Response Induction.1
370815092023Blockade of CCR4 breaks immune tolerance in chronic hepatitis B patients by modulating regulatory pathways.0
378464902023CCR4-NOT differentially controls host versus virus poly(a)-tail length and regulates HCMV infection.3
370175292023Contributions of Ccr4 and Gcn2 to the Translational Response of C. neoformans to Host-Relevant Stressors and Integrated Stress Response Induction.1
370815092023Blockade of CCR4 breaks immune tolerance in chronic hepatitis B patients by modulating regulatory pathways.0
378464902023CCR4-NOT differentially controls host versus virus poly(a)-tail length and regulates HCMV infection.3
351775912022Targeting CCL2-CCR4 axis suppress cell migration of head and neck squamous cell carcinoma.10
352223622022FOXP3/HAT1 Axis Controls Treg Infiltration in the Tumor Microenvironment by Inducing CCR4 Expression in Breast Cancer.21
351775912022Targeting CCL2-CCR4 axis suppress cell migration of head and neck squamous cell carcinoma.10
352223622022FOXP3/HAT1 Axis Controls Treg Infiltration in the Tumor Microenvironment by Inducing CCR4 Expression in Breast Cancer.21
329149442021Immune signature of CCR7(+) central memory T cells associates with disease severity and Immunoglobulin E in bronchial asthma.4
336686482021Identification of Phosphorylated Amino Acids in Human TNRC6A C-Terminal Region and Their Effects on the Interaction with the CCR4-NOT Complex.1
337844172021Upregulation of CCR4 in activated CD8(+) T cells indicates enhanced lung homing in patients with severe acute SARS-CoV-2 infection.20
348874192021RNF219 attenuates global mRNA decay through inhibition of CCR4-NOT complex-mediated deadenylation.13
329149442021Immune signature of CCR7(+) central memory T cells associates with disease severity and Immunoglobulin E in bronchial asthma.4

Citation

Dessen P

CCR4 (C-C motif chemokine receptor 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45869/css/meetings/haematological-explorer/