LHB (luteinizing hormone subunit beta)

2007-02-01 Affiliation

Identity

HGNC

LHB

LOCATION

19q13.33

LOCUSID

3972

ALIAS

CGB4,HH23,LSH-B,LSH-beta

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3972
MIM: 152780
HGNC: 6584
Ensembl: ENSG00000104826

Variants:

dbSNP: 3972
ClinVar: 3972
TCGA: ENSG00000104826
COSMIC: LHB

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000104826	ENST00000649238	P01229
ENSG00000104826	ENST00000649238	A0A0F7RQE6

Expression (GTEx)

500

1000

1500

2000

2500

3000

3500

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuroactive ligand-receptor interaction	KEGG	ko04080
GnRH signaling pathway	KEGG	ko04912
Neuroactive ligand-receptor interaction	KEGG	hsa04080
GnRH signaling pathway	KEGG	hsa04912
Ovarian steroidogenesis	KEGG	hsa04913
Ovarian steroidogenesis	KEGG	ko04913
Prolactin signaling pathway	KEGG	hsa04917
Prolactin signaling pathway	KEGG	ko04917
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Asparagine N-linked glycosylation	REACTOME	R-HSA-446203
Transport to the Golgi and subsequent modification	REACTOME	R-HSA-948021
N-glycan antennae elongation in the medial/trans-Golgi	REACTOME	R-HSA-975576
Reactions specific to the complex N-glycan synthesis pathway	REACTOME	R-HSA-975578
Peptide hormone metabolism	REACTOME	R-HSA-2980736
Peptide hormone biosynthesis	REACTOME	R-HSA-209952
Glycoprotein hormones	REACTOME	R-HSA-209822
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Hormone ligand-binding receptors	REACTOME	R-HSA-375281
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (s) signalling events	REACTOME	R-HSA-418555
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Metabolism of steroid hormones	REACTOME	R-HSA-196071
Mineralocorticoid biosynthesis	REACTOME	R-HSA-193993
Androgen biosynthesis	REACTOME	R-HSA-193048

Protein levels (Protein atlas)

Not detected

Low

Medium

High

cerebral cortex

cerebellum

hippocampus

caudate

thyroid gland

parathyroid gland

adrenal gland

pituitary gland

nasopharynx

bronchus

lung

oral mucosa

salivary gland

esophagus

stomach 1

stomach 2

duodenum

small intestine

colon

rectum

liver

gallbladder

pancreas

kidney

urinary bladder

testis

epididymis

seminal vesicle

prostate

vagina

ovary

fallopian tube

endometrium 1

endometrium 2

cervix, uterine

placenta

breast

heart muscle

smooth muscle

skeletal muscle

soft tissue 1

soft tissue 2

adipose tissue

skin 1

skin 2

appendix

spleen

lymph node

tonsil

bone marrow

References

Pubmed ID	Year	Title	Citations
34090968	2021	Proliferating primary pituitary cells as a model for studying regulation of gonadotrope chromatin and gene expression.	1
34606618	2021	Single molecule characterization of the binding kinetics of a transcription factor and its modulation by DNA sequence and methylation.	3
34090968	2021	Proliferating primary pituitary cells as a model for studying regulation of gonadotrope chromatin and gene expression.	1
34606618	2021	Single molecule characterization of the binding kinetics of a transcription factor and its modulation by DNA sequence and methylation.	3
32185793	2020	A genome-wide association study identifies FSHR rs2300441 associated with follicle-stimulating hormone levels.	5
32475064	2020	Elevated circulating luteinizing hormone levels are associated with diabetic macroalbuminuria in Chinese men and postmenopausal women: A cross-sectional study.	1
32185793	2020	A genome-wide association study identifies FSHR rs2300441 associated with follicle-stimulating hormone levels.	5
32475064	2020	Elevated circulating luteinizing hormone levels are associated with diabetic macroalbuminuria in Chinese men and postmenopausal women: A cross-sectional study.	1
29476300	2018	Homozygous nonsense mutation Trp28X in the LHB gene causes male hypogonadism.	7
30173455	2018	[Correlation of the single nucleotide polymorphisms rs34349826 and rs6521 of the LHB gene with male infertility in Chinese men].	0
29476300	2018	Homozygous nonsense mutation Trp28X in the LHB gene causes male hypogonadism.	7
30173455	2018	[Correlation of the single nucleotide polymorphisms rs34349826 and rs6521 of the LHB gene with male infertility in Chinese men].	0
26662070	2016	Association between genes encoding components of the Leutinizing hormone/Luteinizing hormone-choriogonadotrophin receptor pathway and polycystic ovary syndrome in Egyptian women.	9
27215137	2016	Luteinizing Hormone Secretion during Gonadotropin-Releasing Hormone Stimulation Tests in Obese Girls with Central Precocious Puberty.	11
27656125	2016	A vital region for human glycoprotein hormone trafficking revealed by an LHB mutation.	16

Citation

Dessen P

LHB (luteinizing hormone subunit beta)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45872