Identity
HGNC
LOCATION
3p21.2
LOCUSID
ALIAS
ALAS,ALAS-H,ALAS3,ALASH,MIG4
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 211
MIM: 125290
HGNC: 396
Ensembl: ENSG00000023330
Variants:
dbSNP: 211
ClinVar: 211
TCGA: ENSG00000023330
COSMIC: ALAS1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 34704252 | 2021 | Heme-dependent recognition of 5-aminolevulinate synthase by the human mitochondrial molecular chaperone ClpX. | 3 |
| 34704252 | 2021 | Heme-dependent recognition of 5-aminolevulinate synthase by the human mitochondrial molecular chaperone ClpX. | 3 |
| 32270771 | 2020 | Inhibition of ALAS1 activity exerts anti-tumour effects on colorectal cancer in vitro. | 7 |
| 33199206 | 2020 | 5-Aminolevulinate dehydratase porphyria: Update on hepatic 5-aminolevulinic acid synthase induction and long-term response to hemin. | 5 |
| 32270771 | 2020 | Inhibition of ALAS1 activity exerts anti-tumour effects on colorectal cancer in vitro. | 7 |
| 33199206 | 2020 | 5-Aminolevulinate dehydratase porphyria: Update on hepatic 5-aminolevulinic acid synthase induction and long-term response to hemin. | 5 |
| 28874591 | 2017 | Mutation in human CLPX elevates levels of δ-aminolevulinate synthase and protoporphyrin IX to promote erythropoietic protoporphyria. | 41 |
| 28874591 | 2017 | Mutation in human CLPX elevates levels of δ-aminolevulinate synthase and protoporphyrin IX to promote erythropoietic protoporphyria. | 41 |
| 27496948 | 2016 | Novel Mechanisms for Heme-dependent Degradation of ALAS1 Protein as a Component of Negative Feedback Regulation of Heme Biosynthesis. | 52 |
| 27496948 | 2016 | Novel Mechanisms for Heme-dependent Degradation of ALAS1 Protein as a Component of Negative Feedback Regulation of Heme Biosynthesis. | 52 |
| 26062020 | 2015 | Liver Transplantation for Acute Intermittent Porphyria: Biochemical and Pathologic Studies of the Explanted Liver. | 23 |
| 26062020 | 2015 | Liver Transplantation for Acute Intermittent Porphyria: Biochemical and Pathologic Studies of the Explanted Liver. | 23 |
| 23024262 | 2012 | Nuclear receptor 5A (NR5A) family regulates 5-aminolevulinic acid synthase 1 (ALAS1) gene expression in steroidogenic cells. | 8 |
| 23024262 | 2012 | Nuclear receptor 5A (NR5A) family regulates 5-aminolevulinic acid synthase 1 (ALAS1) gene expression in steroidogenic cells. | 8 |
| 21048031 | 2011 | Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph. | 5 |
Citation
Dessen P
ALAS1 (5-aminolevulinate synthase 1)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/45873/alas1
