ITPKA (inositol-trisphosphate 3-kinase A)

2007-02-01  

Identity

HGNC
ITPKA
LOCATION
15q15.1
LOCUSID
3706
ALIAS
IP3-3KA,IP3KA
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3706
MIM: 147521
HGNC: 6178
Ensembl: ENSG00000137825

Variants:

dbSNP: 3706
ClinVar: 3706
TCGA: ENSG00000137825
COSMIC: ITPKA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137825ENST00000260386P23677
ENSG00000137825ENST00000425927C9JC74

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Inositol phosphate metabolismKEGGko00562
Calcium signaling pathwayKEGGko04020
Phosphatidylinositol signaling systemKEGGko04070
Inositol phosphate metabolismKEGGhsa00562
Calcium signaling pathwayKEGGhsa04020
Phosphatidylinositol signaling systemKEGGhsa04070
Metabolic pathwaysKEGGhsa01100
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4KEGGhsa_M00130
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4KEGGM00130
MetabolismREACTOMER-HSA-1430728
Inositol phosphate metabolismREACTOMER-HSA-1483249
Synthesis of IP3 and IP4 in the cytosolREACTOMER-HSA-1855204

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
366889442023The actin bundling activity of ITPKA mainly accounts for its migration-promoting effect in lung cancer cells.1
376649852023Commentary on: The actin bundling activity of ITPKA mainly accounts for its migration-promoting effect in lung cancer cells.0
366889442023The actin bundling activity of ITPKA mainly accounts for its migration-promoting effect in lung cancer cells.1
376649852023Commentary on: The actin bundling activity of ITPKA mainly accounts for its migration-promoting effect in lung cancer cells.0
336244552021Relationship of ITPKA expression with the prognosis of breast cancer.1
338796332021ITPKA induces cell senescence, inhibits ovarian cancer tumorigenesis and can be downregulated by miR-203.2
336244552021Relationship of ITPKA expression with the prognosis of breast cancer.1
338796332021ITPKA induces cell senescence, inhibits ovarian cancer tumorigenesis and can be downregulated by miR-203.2
320156862020TFAP2A Induced ITPKA Serves as an Oncogene and Interacts with DBN1 in Lung Adenocarcinoma.14
320156862020TFAP2A Induced ITPKA Serves as an Oncogene and Interacts with DBN1 in Lung Adenocarcinoma.14
304667862019PKA-dependent phosphorylation of IP3K-A at Ser119 regulates a binding affinity with EB3.1
304667862019PKA-dependent phosphorylation of IP3K-A at Ser119 regulates a binding affinity with EB3.1
272346022016ITPKA Gene Body Methylation Regulates Gene Expression and Serves as an Early Diagnostic Marker in Lung and Other Cancers.28
272346022016ITPKA Gene Body Methylation Regulates Gene Expression and Serves as an Early Diagnostic Marker in Lung and Other Cancers.28
262490312015ITPKA expression is a novel prognostic factor in hepatocellular carcinoma.7

Citation

Dessen P

ITPKA (inositol-trisphosphate 3-kinase A)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45875