KRT81 (keratin 81)

KRT81 (keratin 81)

2007-02-01 Affiliation

Identity

HGNC

LOCATION

12q13.13

LOCUSID

ALIAS

HB1,Hb-1,K81,KRTHB1,MLN137,ghHkb1,hHAKB2-1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3887
MIM: 602153
HGNC: 6458
Ensembl: ENSG00000205426

Variants:

dbSNP: 3887
ClinVar: 3887
TCGA: ENSG00000205426
COSMIC: KRT81

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000205426	ENST00000327741	Q14533
ENSG00000205426	ENST00000615839	A0A087X106

Expression (GTEx)

0

1

2

3

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Developmental Biology	REACTOME	R-HSA-1266738
Keratinization	REACTOME	R-HSA-6805567

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
37949677	2024	Ectopic Expression of a Truncated Isoform of Hair Keratin 81 in Breast Cancer Alters Biophysical Characteristics to Promote Metastatic Propensity.	1
37949677	2024	Ectopic Expression of a Truncated Isoform of Hair Keratin 81 in Breast Cancer Alters Biophysical Characteristics to Promote Metastatic Propensity.	1
34591651	2021	KRT81 Knockdown Inhibits Malignant Progression of Melanoma Through Regulating Interleukin-8.	11
34591651	2021	KRT81 Knockdown Inhibits Malignant Progression of Melanoma Through Regulating Interleukin-8.	11
32678982	2020	A Polymorphism at the microRNA Binding Site in the 3' Untranslated Region of KRT81 Is Associated with Breast Cancer.	4
32678982	2020	A Polymorphism at the microRNA Binding Site in the 3' Untranslated Region of KRT81 Is Associated with Breast Cancer.	4
29101303	2018	Pancreatic Ductal Adenocarcinoma Subtyping Using the Biomarkers Hepatocyte Nuclear Factor-1A and Cytokeratin-81 Correlates with Outcome and Treatment Response.	48
29101303	2018	Pancreatic Ductal Adenocarcinoma Subtyping Using the Biomarkers Hepatocyte Nuclear Factor-1A and Cytokeratin-81 Correlates with Outcome and Treatment Response.	48
28405679	2017	Hair keratin KRT81 is expressed in normal and breast cancer cells and contributes to their invasiveness.	15
28405679	2017	Hair keratin KRT81 is expressed in normal and breast cancer cells and contributes to their invasiveness.	15
25557232	2015	Novel KRT83 and KRT86 mutations associated with monilethrix.	5
25716425	2015	A genetic variation in microRNA target site of KRT81 gene is associated with survival in early-stage non-small-cell lung cancer.	12
25557232	2015	Novel KRT83 and KRT86 mutations associated with monilethrix.	5
25716425	2015	A genetic variation in microRNA target site of KRT81 gene is associated with survival in early-stage non-small-cell lung cancer.	12
24530479	2014	A miR-SNP of the KRT81 gene is associated with the prognosis of non-Hodgkin's lymphoma.	6

Citation

Dessen P

KRT81 (keratin 81)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45888/js/web-card-_common.js