FMO3 (flavin containing dimethylaniline monoxygenase 3)

2007-02-01 Affiliation

Identity

HGNC

FMO3

LOCATION

1q24.3

LOCUSID

2328

ALIAS

FMOII,TMAU,dJ127D3.1

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2328
MIM: 136132
HGNC: 3771
Ensembl: ENSG00000007933

Variants:

dbSNP: 2328
ClinVar: 2328
TCGA: ENSG00000007933
COSMIC: FMO3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000007933	ENST00000367755	P31513
ENSG00000007933	ENST00000367755	A0A024R8Z4
ENSG00000007933	ENST00000472784	V9GYP3
ENSG00000007933	ENST00000479749	V9GZ60

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Drug metabolism - cytochrome P450	KEGG	ko00982
Drug metabolism - cytochrome P450	KEGG	hsa00982
Metabolism	REACTOME	R-HSA-1430728
Biological oxidations	REACTOME	R-HSA-211859
Phase 1 - Functionalization of compounds	REACTOME	R-HSA-211945
FMO oxidises nucleophiles	REACTOME	R-HSA-217271

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA130620651	anthracyclines and related substances	Chemical	ClinicalAnnotation	associated		PD	21900104, 23441093
PA134308647	rosuvastatin	Chemical	ClinicalAnnotation	associated		PD	20679960
PA152432599	itopride	Chemical	ClinicalAnnotation	associated	PK		25224784
PA445062	Neoplasms	Disease	ClinicalAnnotation	associated		PD	21900104, 23441093
PA445876	Tobacco Use Disorder	Disease	ClinicalAnnotation	associated	PK		28290528
PA447247	liver transplantation	Disease	VariantAnnotation	associated	PK		28084894
PA449212	daunorubicin	Chemical	MultilinkAnnotation	associated			25119182
PA450626	nicotine	Chemical	ClinicalAnnotation	associated	PK		28290528
PA450688	olanzapine	Chemical	ClinicalAnnotation	associated	PK		23147717
PA451565	sulindac	Chemical	ClinicalAnnotation	associated	PK
PA451578	tacrolimus	Chemical	VariantAnnotation	associated	PK		28084894
PA451581	tamoxifen	Chemical	Pathway	associated			23962908

References

Pubmed ID	Year	Title	Citations
38280279	2024	Rare but impaired flavin-containing monooxygenase 3 (FMO3) variants reported in a recently updated Japanese mega-databank of genome resources.	0
38280279	2024	Rare but impaired flavin-containing monooxygenase 3 (FMO3) variants reported in a recently updated Japanese mega-databank of genome resources.	0
36889044	2023	A family study of compound variants of flavin-containing monooxygenase 3 (FMO3) in Japanese subjects found by urinary phenotyping for trimethylaminuria.	0
37148485	2023	Estimation of FMO3 Ontogeny by Mechanistic Population Pharmacokinetic Modelling of Risdiplam and Its Impact on Drug-Drug Interactions in Children.	3
36889044	2023	A family study of compound variants of flavin-containing monooxygenase 3 (FMO3) in Japanese subjects found by urinary phenotyping for trimethylaminuria.	0
37148485	2023	Estimation of FMO3 Ontogeny by Mechanistic Population Pharmacokinetic Modelling of Risdiplam and Its Impact on Drug-Drug Interactions in Children.	3
35348964	2022	Possible correlation between high circulatory levels of trimethylamine-N-oxide and 2177G>C polymorphisms of hepatic flavin containing monooxygenase 3 in Kurdish Population with non-alcoholic fatty liver disease.	1
35348964	2022	Possible correlation between high circulatory levels of trimethylamine-N-oxide and 2177G>C polymorphisms of hepatic flavin containing monooxygenase 3 in Kurdish Population with non-alcoholic fatty liver disease.	1
32998136	2021	Predictive Value of FMO3 Variants on Plasma Disposition and Adverse Reactions of Oral Voriconazole in Febrile Neutropenia.	4
33152328	2021	N- and S-oxygenation activity of truncated human flavin-containing monooxygenase 3 and its common polymorphic variants.	2
34509493	2021	Human flavin-containing monooxygenase 1 and its long-sought hydroperoxyflavin intermediate.	3
34834137	2021	Adaptive Modelling of Mutated FMO3 Enzyme Could Unveil Unexplored Scenarios Linking Variant Haplotypes to TMAU Phenotypes.	2
32998136	2021	Predictive Value of FMO3 Variants on Plasma Disposition and Adverse Reactions of Oral Voriconazole in Febrile Neutropenia.	4
33152328	2021	N- and S-oxygenation activity of truncated human flavin-containing monooxygenase 3 and its common polymorphic variants.	2
34509493	2021	Human flavin-containing monooxygenase 1 and its long-sought hydroperoxyflavin intermediate.	3

Citation

Dessen P

FMO3 (flavin containing dimethylaniline monoxygenase 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45891