Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2328
MIM: 136132
HGNC: 3771
Ensembl: ENSG00000007933
Variants:
dbSNP: 2328
ClinVar: 2328
TCGA: ENSG00000007933
COSMIC: FMO3
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000007933 | ENST00000367755 | P31513 |
| ENSG00000007933 | ENST00000367755 | A0A024R8Z4 |
| ENSG00000007933 | ENST00000472784 | V9GYP3 |
| ENSG00000007933 | ENST00000479749 | V9GZ60 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA130620651 | anthracyclines and related substances | Chemical | ClinicalAnnotation | associated | PD | 21900104, 23441093 | |
| PA134308647 | rosuvastatin | Chemical | ClinicalAnnotation | associated | PD | 20679960 | |
| PA152432599 | itopride | Chemical | ClinicalAnnotation | associated | PK | 25224784 | |
| PA445062 | Neoplasms | Disease | ClinicalAnnotation | associated | PD | 21900104, 23441093 | |
| PA445876 | Tobacco Use Disorder | Disease | ClinicalAnnotation | associated | PK | 28290528 | |
| PA447247 | liver transplantation | Disease | VariantAnnotation | associated | PK | 28084894 | |
| PA449212 | daunorubicin | Chemical | MultilinkAnnotation | associated | 25119182 | ||
| PA450626 | nicotine | Chemical | ClinicalAnnotation | associated | PK | 28290528 | |
| PA450688 | olanzapine | Chemical | ClinicalAnnotation | associated | PK | 23147717 | |
| PA451565 | sulindac | Chemical | ClinicalAnnotation | associated | PK | ||
| PA451578 | tacrolimus | Chemical | VariantAnnotation | associated | PK | 28084894 | |
| PA451581 | tamoxifen | Chemical | Pathway | associated | 23962908 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38280279 | 2024 | Rare but impaired flavin-containing monooxygenase 3 (FMO3) variants reported in a recently updated Japanese mega-databank of genome resources. | 0 |
| 38280279 | 2024 | Rare but impaired flavin-containing monooxygenase 3 (FMO3) variants reported in a recently updated Japanese mega-databank of genome resources. | 0 |
| 36889044 | 2023 | A family study of compound variants of flavin-containing monooxygenase 3 (FMO3) in Japanese subjects found by urinary phenotyping for trimethylaminuria. | 0 |
| 37148485 | 2023 | Estimation of FMO3 Ontogeny by Mechanistic Population Pharmacokinetic Modelling of Risdiplam and Its Impact on Drug-Drug Interactions in Children. | 3 |
| 36889044 | 2023 | A family study of compound variants of flavin-containing monooxygenase 3 (FMO3) in Japanese subjects found by urinary phenotyping for trimethylaminuria. | 0 |
| 37148485 | 2023 | Estimation of FMO3 Ontogeny by Mechanistic Population Pharmacokinetic Modelling of Risdiplam and Its Impact on Drug-Drug Interactions in Children. | 3 |
| 35348964 | 2022 | Possible correlation between high circulatory levels of trimethylamine-N-oxide and 2177G>C polymorphisms of hepatic flavin containing monooxygenase 3 in Kurdish Population with non-alcoholic fatty liver disease. | 1 |
| 35348964 | 2022 | Possible correlation between high circulatory levels of trimethylamine-N-oxide and 2177G>C polymorphisms of hepatic flavin containing monooxygenase 3 in Kurdish Population with non-alcoholic fatty liver disease. | 1 |
| 32998136 | 2021 | Predictive Value of FMO3 Variants on Plasma Disposition and Adverse Reactions of Oral Voriconazole in Febrile Neutropenia. | 4 |
| 33152328 | 2021 | N- and S-oxygenation activity of truncated human flavin-containing monooxygenase 3 and its common polymorphic variants. | 2 |
| 34509493 | 2021 | Human flavin-containing monooxygenase 1 and its long-sought hydroperoxyflavin intermediate. | 3 |
| 34834137 | 2021 | Adaptive Modelling of Mutated FMO3 Enzyme Could Unveil Unexplored Scenarios Linking Variant Haplotypes to TMAU Phenotypes. | 2 |
| 32998136 | 2021 | Predictive Value of FMO3 Variants on Plasma Disposition and Adverse Reactions of Oral Voriconazole in Febrile Neutropenia. | 4 |
| 33152328 | 2021 | N- and S-oxygenation activity of truncated human flavin-containing monooxygenase 3 and its common polymorphic variants. | 2 |
| 34509493 | 2021 | Human flavin-containing monooxygenase 1 and its long-sought hydroperoxyflavin intermediate. | 3 |
Citation
Dessen P
FMO3 (flavin containing dimethylaniline monoxygenase 3)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/45891/fmo3
