STAG1 (stromal antigen 1)

2007-02-01  

Identity

HGNC
STAG1
LOCATION
3q22.3
LOCUSID
10274
ALIAS
MRD47,SA1,SCC3A
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10274
MIM: 604358
HGNC: 11354
Ensembl: ENSG00000118007

Variants:

dbSNP: 10274
ClinVar: 10274
TCGA: ENSG00000118007
COSMIC: STAG1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000118007ENST00000236698Q8WVM7
ENSG00000118007ENST00000383202Q8WVM7
ENSG00000118007ENST00000434713Q68DW7
ENSG00000118007ENST00000480733C9JJQ0
ENSG00000118007ENST00000483235F8WF82
ENSG00000118007ENST00000487065F8WCB3
ENSG00000118007ENST00000492318H7C595
ENSG00000118007ENST00000629124F8WCB3

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
Cell cycleKEGGhsa04110
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
SUMOylationREACTOMER-HSA-2990846
SUMO E3 ligases SUMOylate target proteinsREACTOMER-HSA-3108232
SUMOylation of DNA damage response and repair proteinsREACTOMER-HSA-3108214
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
S PhaseREACTOMER-HSA-69242
Establishment of Sister Chromatid CohesionREACTOMER-HSA-2468052
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813
Mitotic Telophase/CytokinesisREACTOMER-HSA-68884
Cohesin Loading onto ChromatinREACTOMER-HSA-2470946
MeiosisREACTOMER-HSA-1500620
Meiotic synapsisREACTOMER-HSA-1221632

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
387426412024Single-molecule imaging reveals a direct role of CTCF's zinc fingers in SA interaction and cluster-dependent RNA recruitment.0
387426412024Single-molecule imaging reveals a direct role of CTCF's zinc fingers in SA interaction and cluster-dependent RNA recruitment.0
368989922023Different NIPBL requirements of cohesin-STAG1 and cohesin-STAG2.5
368989922023Different NIPBL requirements of cohesin-STAG1 and cohesin-STAG2.5
356547862022Potential role of STAG1 mutations in genetic predisposition to childhood hematological malignancies.1
356547862022Potential role of STAG1 mutations in genetic predisposition to childhood hematological malignancies.1
336276202021PD-L1 regulates genomic stability via interaction with cohesin-SA1 in the nucleus.11
336390732021Whole Exome Sequencing Identifies Cohesin Component STAG1 Mutation in de novo Acute Myeloid Leukemia (FAB M2): A Pilot Study with Cytogenetics, Clinical and Prognostic Implications.0
346480342021STAG2 loss-of-function affects short-range genomic contacts and modulates the basal-luminal transcriptional program of bladder cancer cells.11
336276202021PD-L1 regulates genomic stability via interaction with cohesin-SA1 in the nucleus.11
336390732021Whole Exome Sequencing Identifies Cohesin Component STAG1 Mutation in de novo Acute Myeloid Leukemia (FAB M2): A Pilot Study with Cytogenetics, Clinical and Prognostic Implications.0
346480342021STAG2 loss-of-function affects short-range genomic contacts and modulates the basal-luminal transcriptional program of bladder cancer cells.11
322946122020Specialized functions of cohesins STAG1 and STAG2 in 3D genome architecture.27
324673162020STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers.13
322946122020Specialized functions of cohesins STAG1 and STAG2 in 3D genome architecture.27

Citation

Dessen P

STAG1 (stromal antigen 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45894/haematological-explorer/gene-fusions/gene-explorer/