Identity
HGNC
LOCATION
16p13.3
LOCUSID
ALIAS
TPS1,TPS2,TPSB1,TPSB2,Tryptase-2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 7177
MIM: 191080
HGNC: 12019
Ensembl: ENSG00000172236
Variants:
dbSNP: 7177
ClinVar: 7177
TCGA: ENSG00000172236
COSMIC: TPSAB1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000172236 | ENST00000338844 | Q15661 |
| ENSG00000172236 | ENST00000461509 | J3QTS8 |
| ENSG00000172236 | ENST00000561736 | A0A0C4DGM1 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37818990 | 2024 | Clinical impact of the TPSAB1 genotype in mast cell diseases: A REMA study in a cohort of 959 individuals. | 4 |
| 37818990 | 2024 | Clinical impact of the TPSAB1 genotype in mast cell diseases: A REMA study in a cohort of 959 individuals. | 4 |
| 32717252 | 2021 | Heritable risk for severe anaphylaxis associated with increased α-tryptase-encoding germline copy number at TPSAB1. | 58 |
| 32777817 | 2021 | Hereditary α tryptasemia is a valid genetic biomarker for severe mediator-related symptoms in mastocytosis. | 47 |
| 32717252 | 2021 | Heritable risk for severe anaphylaxis associated with increased α-tryptase-encoding germline copy number at TPSAB1. | 58 |
| 32777817 | 2021 | Hereditary α tryptasemia is a valid genetic biomarker for severe mediator-related symptoms in mastocytosis. | 47 |
| 32709152 | 2020 | Mast Cell β-Tryptase Is Enzymatically Stabilized by DNA. | 10 |
| 32709152 | 2020 | Mast Cell β-Tryptase Is Enzymatically Stabilized by DNA. | 10 |
| 30641266 | 2019 | Tissue engineered human prostate microtissues reveal key role of mast cell-derived tryptase in potentiating cancer-associated fibroblast (CAF)-induced morphometric transition in vitro. | 21 |
| 31209239 | 2019 | Adipose Tissue Mast Cells Promote Human Adipose Beiging in Response to Cold. | 21 |
| 31337736 | 2019 | Impact of naturally forming human α/β-tryptase heterotetramers in the pathogenesis of hereditary α-tryptasemia. | 32 |
| 30641266 | 2019 | Tissue engineered human prostate microtissues reveal key role of mast cell-derived tryptase in potentiating cancer-associated fibroblast (CAF)-induced morphometric transition in vitro. | 21 |
| 31209239 | 2019 | Adipose Tissue Mast Cells Promote Human Adipose Beiging in Response to Cold. | 21 |
| 31337736 | 2019 | Impact of naturally forming human α/β-tryptase heterotetramers in the pathogenesis of hereditary α-tryptasemia. | 32 |
| 27545065 | 2017 | Humoral and cellular responses to casein in patients with food protein-induced enterocolitis to cow's milk. | 26 |
Citation
Dessen P
TPSAB1 (tryptase alpha/beta 1)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/45901/tpsab1
