STX2 (syntaxin 2)

2007-02-01  

Identity

HGNC
STX2
LOCATION
12q24.33
LOCUSID
2054
ALIAS
EPIM,EPM,STX2A,STX2B,STX2C
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2054
MIM: 132350
HGNC: 3403
Ensembl: ENSG00000111450

Variants:

dbSNP: 2054
ClinVar: 2054
TCGA: ENSG00000111450
COSMIC: STX2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111450ENST00000261653P32856
ENSG00000111450ENST00000344271J3KNU7
ENSG00000111450ENST00000392373P32856

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
SNARE interactions in vesicular transportKEGGko04130
SNARE interactions in vesicular transportKEGGhsa04130
Synaptic vesicle cycleKEGGko04721
Synaptic vesicle cycleKEGGhsa04721

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
363163162022Plasma membrane flipping of Syntaxin-2 regulates its inhibitory action on insulin granule exocytosis.2
363163162022Plasma membrane flipping of Syntaxin-2 regulates its inhibitory action on insulin granule exocytosis.2
330753732020STX2 drives colorectal cancer proliferation via upregulation of EXOSC4.4
330753732020STX2 drives colorectal cancer proliferation via upregulation of EXOSC4.4
295702322018STX2 is a causative gene for nonobstructive azoospermia.8
297672402018Munc13‑4 mediates human neutrophil elastase‑induced airway mucin5AC hypersecretion by interacting with syntaxin2.1
298554622018STX2 promotes colorectal cancer metastasis through a positive feedback loop that activates the NF-κB pathway.14
295702322018STX2 is a causative gene for nonobstructive azoospermia.8
297672402018Munc13‑4 mediates human neutrophil elastase‑induced airway mucin5AC hypersecretion by interacting with syntaxin2.1
298554622018STX2 promotes colorectal cancer metastasis through a positive feedback loop that activates the NF-κB pathway.14
282092942017Sulfated glycosaminoglycans and non-classically secreted proteins, basic FGF and epimorphin, coordinately regulate TGF-β-induced cell behaviors of human scar dermal fibroblasts.2
282092942017Sulfated glycosaminoglycans and non-classically secreted proteins, basic FGF and epimorphin, coordinately regulate TGF-β-induced cell behaviors of human scar dermal fibroblasts.2
273628462016HIV and HCV Co-Culture Promotes Profibrogenic Gene Expression through an Epimorphin-Mediated ERK Signaling Pathway in Hepatic Stellate Cells.5
273628462016HIV and HCV Co-Culture Promotes Profibrogenic Gene Expression through an Epimorphin-Mediated ERK Signaling Pathway in Hepatic Stellate Cells.5
245783792014Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2.24

Citation

Dessen P

STX2 (syntaxin 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45908