GAL (galanin and GMAP prepropeptide)

2007-02-01 Affiliation

Identity

HGNC

GAL

LOCATION

11q13.2

LOCUSID

51083

ALIAS

ETL8,GAL-GMAP,GALN,GLNN,GMAP

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 51083
MIM: 137035
HGNC: 4114
Ensembl: ENSG00000069482

Variants:

dbSNP: 51083
ClinVar: 51083
TCGA: ENSG00000069482
COSMIC: GAL

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000069482	ENST00000265643	P22466

Expression (GTEx)

100

200

300

400

500

600

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Peptide ligand-binding receptors	REACTOME	R-HSA-375276
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (i) signalling events	REACTOME	R-HSA-418594

Protein levels (Protein atlas)

Not detected

Low

Medium

High

cerebral cortex

cerebellum

hippocampus

caudate

hypothalamus

thyroid gland

parathyroid gland

adrenal gland

pituitary gland

nasopharynx

bronchus

lung

oral mucosa

salivary gland

esophagus

stomach 1

stomach 2

duodenum

small intestine

colon

rectum

liver

gallbladder

pancreas

kidney

urinary bladder

testis

epididymis

seminal vesicle

prostate

vagina

ovary

fallopian tube

endometrium 1

endometrium 2

cervix, uterine

placenta

breast

heart muscle

smooth muscle

skeletal muscle

soft tissue 1

soft tissue 2

adipose tissue

skin 1

skin 2

appendix

spleen

lymph node

tonsil

bone marrow

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD
PA10402	benzodiazepine derivatives	Chemical	ClinicalAnnotation	associated	PD
PA164713257	Selective serotonin reuptake inhibitors	Chemical	ClinicalAnnotation	associated	PD
PA444460	Heroin Dependence	Disease	ClinicalAnnotation	associated	PD
PA445043	Opioid-Related Disorders	Disease	ClinicalAnnotation	associated
PA447321	Depressive Disorder, Major	Disease	ClinicalAnnotation	associated	PD
PA450522	mirtazapine	Chemical	ClinicalAnnotation	associated	PD
PA452229	antidepressants	Chemical	ClinicalAnnotation	associated	PD
PA452618	opioids	Chemical	ClinicalAnnotation	associated
PA452619	heroin	Chemical	ClinicalAnnotation	associated	PD

References

Pubmed ID	Year	Title	Citations
33534034	2022	Serum Galanin in Children with Autism Spectrum Disorder.	3
35913979	2022	Structure of the human galanin receptor 2 bound to galanin and Gq reveals the basis of ligand specificity and how binding affects the G-protein interface.	0
33534034	2022	Serum Galanin in Children with Autism Spectrum Disorder.	3
35913979	2022	Structure of the human galanin receptor 2 bound to galanin and Gq reveals the basis of ligand specificity and how binding affects the G-protein interface.	0
34925648	2021	Increased Serum Neuropeptide Galanin Level Is a Predictor of Cognitive Dysfunction in Patients with Hip Fracture.	0
34925648	2021	Increased Serum Neuropeptide Galanin Level Is a Predictor of Cognitive Dysfunction in Patients with Hip Fracture.	0
32757697	2020	Further evidence for the association of GAL, GALR1 and NPY1R variants with opioid dependence.	1
33552060	2020	Review: Occurrence and Distribution of Galanin in the Physiological and Inflammatory States in the Mammalian Gastrointestinal Tract.	12
32757697	2020	Further evidence for the association of GAL, GALR1 and NPY1R variants with opioid dependence.	1
33552060	2020	Review: Occurrence and Distribution of Galanin in the Physiological and Inflammatory States in the Mammalian Gastrointestinal Tract.	12
30616468	2019	Galanin expression is down-regulated in patients with gastric cancer.	8
31881033	2019	Association between anxiety and non-coding genetic variants of the galanin neuropeptide.	3
30616468	2019	Galanin expression is down-regulated in patients with gastric cancer.	8
31881033	2019	Association between anxiety and non-coding genetic variants of the galanin neuropeptide.	3
28987550	2018	Implication of galanin gene rs948854 polymorphism in depressive symptoms in adolescents.	3

Citation

Dessen P

GAL (galanin and GMAP prepropeptide)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45909